RSPH9 and TAF8

Data Source: HiPPIP (Novel)

		RSPH9	TAF8
Name		radial spoke head component 9	TATA-box binding protein associated factor 8
Structure
GO Annotations	Cellular Component	Radial Spoke Radial Spoke Head Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Kinocilium 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3	Nucleus Nucleoplasm Transcription Factor TFIID Complex Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Protein Heterodimerization Activity
	Biological Process	Cilium Movement Cell Projection Organization Axoneme Assembly Motile Cilium Assembly Cilium Movement Involved In Cell Motility Radial Spoke Assembly Axonemal Central Apparatus Assembly	DNA-templated Transcription Open Complex Formation Inner Cell Mass Cell Proliferation Transcription Initiation At RNA Polymerase II Promoter Cell Differentiation MRNA Transcription By RNA Polymerase II Regulation Of Fat Cell Differentiation RNA Polymerase II Preinitiation Complex Assembly Maintenance Of Protein Location In Nucleus Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		None	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome	None
GWAS		Intracranial aneurysm ( 29531279 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244 ) Exploratory eye movement dysfunction in schizophrenia (number of eye fixations) ( 26242244 ) Exploratory eye movement dysfunction in schizophrenia (responsive search score) ( 26242244 ) HDL cholesterol levels ( 28334899 ) Hemoglobin levels ( 33491795 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) Neutrophil percentage of white cells ( 32888494 )
Novel Interactors		9 novel interactors: ADCY10P1 DRC5 KLHDC3 LINC03040 LRRC73 OARD1 SPATS1 TAF8 TSPO2	2 novel interactors: DRC5 RSPH9
Interacting Genes		2 interacting genes: HMG20A PNMA1	13 interacting genes: H3-4 KPNA2 KPNB1 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF7 TAF9
Entrez ID		221421	129685
HPRD ID		12875	18167
Ensembl ID		ENSG00000172426	ENSG00000137413
Uniprot IDs		Q9H1X1	A0A8I5KXI2 A0A8I5QL44 Q7Z7C8
PDB IDs		8J07	4WV4 4WV6 5FUR 6MZC 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGG 7EGH 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
GO Terms Enriched among Interactors		DNA-templated Transcription Open Complex Formation ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity	Transcription Factor TFIID Complex RNA Polymerase II General Transcription Initiation Factor Activity MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Transcription Factor TFTC Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter Protein-DNA Complex Assembly Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of DNA Repair MRNA Metabolic Process Protein-containing Complex Assembly Protein-containing Complex Organization MLL1 Complex Regulation Of DNA Metabolic Process Protein Heterodimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Component Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process SAGA Complex Regulation Of Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Positive Regulation Of Biosynthetic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process TBP-class Protein Binding Histone Acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Male Germ Cell Nucleus Aryl Hydrocarbon Receptor Binding