FLCN and RRAGA

Number of citations of the paper that reports this interaction (PubMedID 24081491)
70

Data Source:
BioGRID (pull down)

		FLCN	RRAGA
Description		folliculin	Ras related GTP binding A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Midbody Cell Projection Cell-cell Contact Zone Mitotic Spindle FNIP-folliculin RagC/D GAP	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane GATOR1 Complex Gtr1-Gtr2 GTPase Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Enzyme Inhibitor Activity GTPase Activator Activity Protein Binding Enzyme Binding Protein-containing Complex Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Protein Heterodimerization Activity Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lysosome Organization Cell-cell Junction Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cell Proliferation Involved In Kidney Development Energy Homeostasis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Negative Regulation Of Lysosome Organization Regulation Of Pro-B Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Autophagosome Assembly Cytoplasmic Translation Apoptotic Process Intracellular Protein Localization Cellular Response To Starvation Negative Regulation Of Autophagy Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Intracellular Signal Transduction TORC1 Signaling Glucose Homeostasis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Cellular Response To Methionine Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Protein Localization To Membrane Positive Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes E3 ubiquitin ligases ubiquitinate target proteins Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases		Birt-Hogg-Dube syndrome Renal cell carcinoma
GWAS		Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		12 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS RRAGA TMEFF1 TSTD2	5 interacting genes: DYNLT1 FLCN IL7R NOL8 RRAGC
Entrez ID		201163	10670
HPRD ID		06278	10205
Ensembl ID		ENSG00000154803	ENSG00000155876
Uniprot IDs		A0A0S2Z5Y7 Q8NFG4	Q7L523
PDB IDs		3V42 6NZD 6ULG 8DHB	5X6V 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Fructose Metabolic Process Regulation Of Carbohydrate Catabolic Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagosome Assembly Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Carbohydrate Biosynthetic Process Response To Salt Stress Regulation Of Generation Of Precursor Metabolites And Energy Vacuole Organization Response To Nutrient Levels Cellular Response To Starvation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Fructose-1-phosphate Aldolase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP CTP Binding DATP Binding Response To Starvation Cellular Response To Nutrient Levels Autophagosome Membrane Autophagosome Maturation N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Mitophagy Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Autophagy Regulation Of Small Molecule Metabolic Process Negative Regulation Of Pentose-phosphate Shunt Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Osmotic Stress Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity	FNIP-folliculin RagC/D GAP Lysosome Organization Negative Regulation Of Protein Localization To Nucleus Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Protein Destabilization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of TOR Signaling TOR Signaling Regulation Of TORC1 Signaling Interleukin-7 Receptor Activity Intracellular Transport Of Viral Protein In Host Cell Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Hemopoiesis Vacuole Organization Cellular Response To Starvation Gtr1-Gtr2 GTPase Complex Negative Regulation Of Lysosome Organization Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Protein Localization Response To Starvation Spindle Interleukin-7-mediated Signaling Pathway Positive Regulation Of T Cell Differentiation In Thymus Intracellular Transport Of Virus Cellular Response To Nutrient Levels Regulation Of Pro-B Cell Differentiation Host Cell Secretory Vesicle Negative Regulation Of T Cell Mediated Cytotoxicity Cell Proliferation Involved In Kidney Development Protein Localization To Nucleolus Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of Signal Transduction Lysosomal Membrane Regulation Of Protein Stability Regulation Of Autophagy Regulation Of Lysosome Organization Negative Regulation Of Catabolic Process Enzyme-substrate Adaptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
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