ALDH1A3 and USP9X

Number of citations of the paper that reports this interaction (PubMedID 30958800)
46

Data Source:
BioGRID (enzymatic study)

		ALDH1A3	USP9X
Description		aldehyde dehydrogenase 1 family member A3	ubiquitin specific peptidase 9 X-linked
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection
	Molecular Function	Retinal Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Thyroid Hormone Binding NAD+ Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Optic Cup Morphogenesis Involved In Camera-type Eye Development Retinoic Acid Biosynthetic Process Aldehyde Metabolic Process Lipid Metabolic Process Apoptotic Process Locomotory Behavior Nucleus Accumbens Development Embryonic Camera-type Eye Development Inner Ear Morphogenesis Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process Positive Regulation Of Apoptotic Process Nose Development Embryonic Eye Morphogenesis Neuromuscular Process Controlling Balance Protein Homotetramerization Righting Reflex Olfactory Pit Development Face Development Harderian Gland Development	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation
Pathways		RA biosynthesis pathway Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs		NADH Vitamin A
Diseases
GWAS		Chin dimples ( 27182965) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Migraine ( 27322543)
Interacting Genes		1 interacting genes: USP9X	32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL
Entrez ID		220	8239
HPRD ID		02713	02091
Ensembl ID		ENSG00000184254	ENSG00000124486
Uniprot IDs		H0Y2X5 P47895	A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008
PDB IDs		5FHZ 6S6W 6TE5 6TGW 6TRY 7A6Q 7QK7 7QK8 7QK9	5VBD 5WCH 7YXX 7YXY
Enriched GO Terms of Interacting Partners?		K11-linked Deubiquitinase Activity Regulation Of TORC2 Signaling Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Import Into Peroxisome Matrix, Receptor Recycling DNA Alkylation Repair Co-SMAD Binding Peroxisomal Membrane Transport Molecular Sequestering Activity Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Cytosolic Ciliogenesis Positive Regulation Of TORC2 Signaling Protein K63-linked Deubiquitination Negative Regulation Of Cilium Assembly Receptor Recycling Deubiquitinase Activity Peroxisome Organization Intracellular Protein Transmembrane Transport Amyloid Fibril Formation Regulation Of Protein Binding Axon Extension Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Binding Receptor Metabolic Process Female Gamete Generation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cysteine-type Endopeptidase Activity Protein Transmembrane Transport Neuron Projection Extension Negative Regulation Of Proteolysis Involved In Protein Catabolic Process BMP Signaling Pathway Positive Regulation Of TOR Signaling Cysteine-type Deubiquitinase Activity Regulation Of Cilium Assembly Protein Deubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Developmental Cell Growth Protein Modification By Small Protein Removal Regulation Of Circadian Rhythm Negative Regulation Of Protein Catabolic Process Growth Cone Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Cysteine-type Peptidase Activity Developmental Growth Involved In Morphogenesis	Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration
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