ALDH1A3

Description		aldehyde dehydrogenase 1 family member A3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Retinal Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Thyroid Hormone Binding NAD+ Binding
	Biological Process	Optic Cup Morphogenesis Involved In Camera-type Eye Development Retinoic Acid Biosynthetic Process Aldehyde Metabolic Process Lipid Metabolic Process Apoptotic Process Locomotory Behavior Nucleus Accumbens Development Embryonic Camera-type Eye Development Inner Ear Morphogenesis Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process Positive Regulation Of Apoptotic Process Nose Development Embryonic Eye Morphogenesis Neuromuscular Process Controlling Balance Protein Homotetramerization Righting Reflex Olfactory Pit Development Face Development Harderian Gland Development
Pathways		RA biosynthesis pathway Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs		NADH Vitamin A
Diseases
GWAS		Chin dimples ( 27182965) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		1 interacting genes: USP9X
Entrez ID		220
HPRD ID		02713
Ensembl ID		ENSG00000184254
Uniprot IDs		H0Y2X5 P47895
PDB IDs		5FHZ 6S6W 6TE5 6TGW 6TRY 7A6Q 7QK7 7QK8 7QK9
Enriched GO Terms of Interacting Partners?		K11-linked Deubiquitinase Activity Regulation Of TORC2 Signaling Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Import Into Peroxisome Matrix, Receptor Recycling DNA Alkylation Repair Co-SMAD Binding Peroxisomal Membrane Transport Molecular Sequestering Activity Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Cytosolic Ciliogenesis Positive Regulation Of TORC2 Signaling Protein K63-linked Deubiquitination Negative Regulation Of Cilium Assembly Receptor Recycling Deubiquitinase Activity Peroxisome Organization Intracellular Protein Transmembrane Transport Amyloid Fibril Formation Regulation Of Protein Binding Axon Extension Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Binding Receptor Metabolic Process Female Gamete Generation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cysteine-type Endopeptidase Activity Protein Transmembrane Transport Neuron Projection Extension Negative Regulation Of Proteolysis Involved In Protein Catabolic Process BMP Signaling Pathway Positive Regulation Of TOR Signaling Cysteine-type Deubiquitinase Activity Regulation Of Cilium Assembly Protein Deubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Developmental Cell Growth Protein Modification By Small Protein Removal Regulation Of Circadian Rhythm Negative Regulation Of Protein Catabolic Process Growth Cone Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Cysteine-type Peptidase Activity Developmental Growth Involved In Morphogenesis
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