ADIPOQ and CDH13

Number of citations of the paper that reports this interaction (PubMedID 15210937)
38

Data Source:
HPRD (in vivo)

		ADIPOQ	CDH13
Description		adiponectin, C1Q and collagen domain containing	cadherin 13
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Cell Surface Extracellular Matrix Protein-containing Complex	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Caveola Adherens Junction Focal Adhesion External Side Of Plasma Membrane Membrane Catenin Complex Extracellular Matrix Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Side Of Membrane GABA-ergic Synapse
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Extracellular Matrix Structural Constituent Protein Binding Sialic Acid Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity	Calcium Ion Binding Protein Binding Beta-catenin Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Cadherin Binding Metal Ion Binding Adiponectin Binding Lipoprotein Particle Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Beta-oxidation Response To Nutrient Circadian Rhythm Response To Xenobiotic Stimulus Response To Bacterium Response To Sucrose Response To Glucose Positive Regulation Of Signal Transduction Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Response To Activity Fatty Acid Oxidation Negative Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Response To Nutrient Levels Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Positive Regulation Of Myeloid Cell Apoptotic Process Adiponectin-activated Signaling Pathway Negative Regulation Of Heterotypic Cell-cell Adhesion Low-density Lipoprotein Particle Clearance Response To Tumor Necrosis Factor Glucose Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAP Kinase Activity Response To Ethanol Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of DNA-templated Transcription Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of D-glucose Import Negative Regulation Of Hormone Secretion Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Negative Regulation Of Synaptic Transmission Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Cholesterol Import Negative Regulation Of ERK1 And ERK2 Cascade Response To Linoleic Acid Detection Of Oxidative Stress Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Response To Epinephrine Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Intracellular Protein Transport Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Receptor Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Renal Albumin Absorption Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Metanephric Mesenchymal Cell Migration	Cell Morphogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Rac Protein Signal Transduction Lamellipodium Assembly Regulation Of Endocytosis Positive Regulation Of Cell Migration Adherens Junction Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelial Cell Migration Keratinocyte Proliferation Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Positive Chemotaxis Regulation Of Transport Localization Within Membrane Low-density Lipoprotein Particle Mediated Signaling Cellular Response To Xenobiotic Stimulus Cellular Response To Toxic Substance Cell-cell Adhesion
Pathways		AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Adherens junctions interactions
Drugs
Diseases		Adiponectin deficiency
GWAS		Activated partial thromboplastin time ( 22703881) Adiponectin levels ( 19165155 20011104 20018283 20876611 21700879 22479202 24105470 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Adiponectin levels in pregnancy ( 28317342) Copper levels ( 26025379)	Adiponectin levels ( 31178129 20876611 20887962 21771975 22065538 22479202 24105470) Adolescent idiopathic scoliosis ( 30395268 31417091) Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Alcohol consumption (heavy vs. light/non-drinkers) ( 27911795) Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756) Blood pressure ( 17903302) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Crohn's disease ( 28067908) D-dimer levels ( 21502573) Daytime sleep phenotypes ( 27126917) Declining hemoglobin trajectory in blood donors ( 33491795) Dental caries (decayed, missing and filled teeth) ( 31533690) Depression (quantitative trait) ( 20800221) Diastolic blood pressure ( 27841878 31170924 30578418) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction ( 30583798) Feeling hurt ( 29500382) Feeling tense ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Gait speed in old age ( 28077804) General risk tolerance (MTAG) ( 30643258) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (Blautia) ( 33208821) Gut microbiota relative abundance (Prevotella) ( 33208821) Height ( 20189936) Hippocampal volume ( 31530798) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hypertension ( 19304780) Hypothyroidism ( 27182965) IgE levels in asthmatics (D.f. specific) ( 23967269) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Leukoderma in response to rhododendrol ( 32558222) Maximal oxygen uptake response ( 25729143) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Oily fish consumption ( 32066663) Periodontitis (Mean PAL) ( 24024966) Pork consumption ( 32066663) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Precuneus cortex volume ( 31530798) Pulse pressure ( 30578418 28739976 28135244 27841878) Rapid automised naming of digits ( 30741946) Refractive astigmatism ( 30306274) Response to amphetamines ( 22952603) Response to antipsychotic treatment ( 20195266) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (adiponectin levels) ( 23149075) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Schizophrenia ( 23358160) Seasonality and depression ( 30217971) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		62 interacting genes: ADIPOR2 AMIGO1 AQP6 ASGR2 BCL2L13 BIK BNIP3L BSND BTNL9 CAMLG CCDC107 CD200R1 CD79A CDH13 CLDN9 CLEC10A CLEC2D CNR2 COQ9 CPLX4 CREB3L1 CYBC1 ERGIC3 ERP29 FAM209A FASN FCGR1A FKBP7 FNDC9 GPR152 GPR42 HSD17B11 IFNGR2 KASH5 KCNK5 KEL MFF MFSD6 MRM1 MS4A3 MUC1 NEMP1 PEX12 PROKR2 PVR SCN3B SGTA SGTB SIGLEC12 SLC16A2 SLC22A23 SLC35E3 SLC35H1 SLC71A2 SYAP1 SYNE4 TMEM179B TMEM237 TMEM35A TMPRSS2 TNFSF14 TRIM35	12 interacting genes: ADIPOQ ANXA1 AURKA CASP8 CCND1 CHEK2 HMMR MAPK6 MTNR1B PTPN1 RAD51 SNCA
Entrez ID		9370	1012
HPRD ID		05671	03219
Ensembl ID		ENSG00000181092	ENSG00000140945
Uniprot IDs		A8K660 B2R773 Q15848	B7Z3H7 B7Z9B1 P55290
PDB IDs		4DOU 6U66 6U6N	2V37
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane TRC Complex External Side Of Plasma Membrane Adiponectin Binding	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Response To Xenobiotic Stimulus Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Protein-containing Complex Regulation Of Cell Cycle Phase Transition Protein Kinase Binding Response To Glycoside Negative Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Cell Cycle Process Regulation Of Neuron Apoptotic Process Response To Alcohol Response To Stress Cellular Response To Epinephrine Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Epinephrine Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Response To Ethanol Response To Magnesium Ion Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Biological Quality Regulation Of Cell Cycle Process Positive Regulation Of Vesicle Fusion Negative Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Cell Cycle Response To Glucocorticoid Negative Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of DNA Damage Checkpoint Response To Ionizing Radiation Enzyme Binding Positive Regulation Of Developmental Process Response To Lipid Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Mitotic Cell Cycle Phase Transition Regulation Of Inflammatory Response Response To Corticosteroid Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Defense Response Response To X-ray Negative Regulation Of Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?