ADIPOQ and ADIPOR2

Number of citations of the paper that reports this interaction (PMID 12802337)
342

Data Source:
HPRD (in vivo)

		ADIPOQ	ADIPOR2
Gene Name		adiponectin, C1Q and collagen domain containing	adiponectin receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Cell Surface Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Cytokine Activity Hormone Activity Protein Binding Sialic Acid Binding Identical Protein Binding Protein Homodimerization Activity	Receptor Activity Hormone Binding Identical Protein Binding Protein Heterodimerization Activity Adiponectin Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Beta-oxidation Response To Nutrient Circadian Rhythm Response To Sucrose Response To Glucose Positive Regulation Of Signal Transduction Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Response To Activity Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Oxidation Negative Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Positive Regulation Of Myeloid Cell Apoptotic Process Adiponectin-activated Signaling Pathway Negative Regulation Of Heterotypic Cell-cell Adhesion Low-density Lipoprotein Particle Clearance Response To Tumor Necrosis Factor Cellular Response To Drug Glucose Homeostasis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Response To Ethanol Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Negative Regulation Of Hormone Secretion Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Phagocytosis Negative Regulation Of Synaptic Transmission Brown Fat Cell Differentiation Protein Homooligomerization Response To Glucocorticoid Membrane Depolarization Membrane Hyperpolarization Protein Heterotrimerization Negative Regulation Of ERK1 And ERK2 Cascade Response To Linoleic Acid Detection Of Oxidative Stress Cellular Response To CAMP Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Response To Epinephrine Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Receptor Binding Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Renal Albumin Absorption Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Metanephric Mesenchymal Cell Migration	Heart Development Female Pregnancy Response To Nutrient Hormone-mediated Signaling Pathway Fatty Acid Oxidation Negative Regulation Of Cell Growth Adiponectin-activated Signaling Pathway Positive Regulation Of Glucose Import
Pathways		Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Adiponectin levels ( 21700879 20876611 20011104 22479202 20018283 19165155)	Adverse response to lamotrigine and phenytoin ( 22379998)
Protein-Protein Interactions		5 interactors: ADIPOR2 CCDC155 CDH13 SGTA SYNE4	1 interactors: ADIPOQ
Entrez ID		9370	79602
HPRD ID		05671	06403
Ensembl ID		ENSG00000181092	ENSG00000006831
Uniprot IDs		A8K660 B2R773 Q15848	Q86V24
PDB IDs		4DOU
Enriched GO Terms of Interacting Partners?		Chromosome Localization To Nuclear Envelope Involved In Synapsis Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Adiponectin-activated Signaling Pathway Low-density Lipoprotein Particle Mediated Signaling Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Monopolar Cell Polarity Cellular Response To Lipoprotein Particle Stimulus Response To Low-density Lipoprotein Particle	Response To Linoleic Acid Positive Regulation Of Renal Albumin Absorption Detection Of Oxidative Stress Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Binding Negative Regulation Of Granulocyte Differentiation Adiponectin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Positive Regulation Of Myeloid Cell Apoptotic Process Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Macrophage Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Heterotrimerization Negative Regulation Of Phagocytosis Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Gluconeogenesis Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Protein Kinase A Signaling Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Receptor Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Migration Cellular Response To Epinephrine Stimulus Response To Sucrose Positive Regulation Of Cholesterol Efflux Response To Epinephrine Positive Regulation Of Cholesterol Transport Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Regulation Of Cholesterol Efflux Negative Regulation Of DNA Biosynthetic Process Low-density Lipoprotein Particle Clearance Cellular Response To Catecholamine Stimulus Regulation Of Protein Autophosphorylation Positive Regulation Of Interleukin-8 Production Positive Regulation Of Fatty Acid Metabolic Process Protein Trimerization Plasma Lipoprotein Particle Clearance
Tagcloud ?		act adjacent apparatus diagnostic downregulated erk future golgi indicated invasion little localized malignancy metastasis migration option osteosarcoma overexpression paired paqr3 progestin promoting providing recently regions specifically suppressor taken understood	balance biologically bonferroni bp candidates chuk connection corrected correction dbp diastolic false fdr framingham heritability ikbkb ikbke miss modest nfkbia plausible positives retn snp snps stringent systolic thresholds variance
Tagcloud (Difference) ?		act adjacent apparatus diagnostic downregulated erk future golgi indicated invasion little localized malignancy metastasis migration option osteosarcoma overexpression paired paqr3 progestin promoting providing recently regions specifically suppressor taken understood	balance biologically bonferroni bp candidates chuk connection corrected correction dbp diastolic false fdr framingham heritability ikbkb ikbke miss modest nfkbia plausible positives retn snp snps stringent systolic thresholds variance
Tagcloud (Intersection) ?