USP12 and NUP58

		USP12	NUP58
Description		ubiquitin specific peptidase 12	nucleoporin 58
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Nuclear Envelope Nuclear Pore Membrane Nuclear Membrane Protein-containing Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Deubiquitinase Activity	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Nucleocytoplasmic Transport Protein Transport Regulation Of Protein Import Into Nucleus MRNA Transport
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Alcohol dependence ( 21314694) Anti-saccade response ( 29064472) Aspartate aminotransferase levels ( 33547301) Mortality in sepsis ( 27639821) Nose morphology ( 29921221) Ulcerative colitis ( 19915573)
Interacting Genes		9 interacting genes: APP BAX CDC73 H2AC20 H2BC21 HMGB1 NOTCH1 RRM2 UBC	19 interacting genes: ABI3 AGR2 APC COG3 COG6 HTT KRT27 KRT28 KRT33B MAPK3 MEIS2 MIS18A NUP62 PKNOX1 PKNOX2 TRAF1 TRIM54 UBQLN1 UBQLN2
Entrez ID		219333	9818
HPRD ID		15631	06355
Ensembl ID		ENSG00000152484	ENSG00000139496
Uniprot IDs		O75317	A0A8Q3WKK5 A0A8Q3WKL7 Q9BVL2
PDB IDs		5K16 5K1A 5K1B 5K1C 5L8W	4JO7 4JO9 4JQ5 5IJN 5IJO 7PER 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis RAGE Receptor Binding Response To External Biotic Stimulus Protein Heterodimerization Activity Regulation Of Epithelial Cell Proliferation Nucleus Positive Regulation Of Monocyte Chemotaxis Apoptotic Process Involved In Morphogenesis Positive Regulation Of Apoptotic Process Chemoattractant Activity Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Monocyte Chemotaxis Apoptotic Process Involved In Development Epithelial Cell Proliferation Negative Regulation Of Fibroblast Proliferation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Programmed Cell Death Regulation Of Chemotaxis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Chemotaxis Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Macrophage Activation Regulation Of ERK1 And ERK2 Cascade Amylin Binding Antibacterial Humoral Response Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Humoral Immune Response T Cell Homeostatic Proliferation BAX Complex Release Of Matrix Enzymes From Mitochondria Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Viral Process Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Positive Regulation Of Cell Cycle G1/S Phase Transition	Positive Regulation Of Protein Localization To Centrosome Regulation Of Protein Localization To Centrosome Organelle Organization Regulation Of Macroautophagy Structural Constituent Of Skin Epidermis Intermediate Filament Organization Positive Regulation Of Response To Endoplasmic Reticulum Stress Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Anatomical Structure Morphogenesis Autophagosome Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Autophagosome Assembly Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Organelle Assembly Autophagosome Organization Regulation Of Organelle Organization Golgi Organization Regulation Of ERAD Pathway Positive Regulation Of Catabolic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Hair Follicle Morphogenesis Identical Protein Binding Positive Regulation Of ERBB Signaling Pathway Intra-Golgi Vesicle-mediated Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Depolymerization Regulation Of Protein Catabolic Process Regulation Of Protein Stability Regulation Of Autophagy Intermediate Filament Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Microtubule Polymerization Or Depolymerization Cytoskeleton Epithelial Cell Differentiation Structural Molecule Activity Vacuole Organization Negative Regulation Of Store-operated Calcium Channel Activity Tissue Morphogenesis Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Peptidyl-tyrosine Phosphorylation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of G Protein-coupled Receptor Internalization
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