STMN2 and TRPC5

Number of citations of the paper that reports this interaction (PubMedID 12858178)
0

Data Source:
HPRD (in vivo, two hybrid)

		STMN2	TRPC5
Description		stathmin 2	transient receptor potential cation channel subfamily C member 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Membrane Lamellipodium Axon Growth Cone Cell Projection Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Dendrite Growth Cone Cation Channel Complex Calcium Channel Complex Neuronal Cell Body Presynapse
	Molecular Function	Protein Binding Tubulin Binding Calcium-dependent Protein Binding	Actin Binding Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Actinin Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Microtubule Depolymerization Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Depolymerization Neuron Projection Development Cellular Response To Nerve Growth Factor Stimulus	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Population Proliferation Neuron Differentiation Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Membrane Hyperpolarization
Pathways		RND1 GTPase cycle	TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS		Creutzfeldt-Jakob disease ( 19081515) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592) Metabolite levels ( 23823483) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834)	Smoking behavior ( 19247474)
Interacting Genes		28 interacting genes: CCDC85A CCHCR1 CDC42 CDK1 CEP70 CTNNA3 EEF1A1 ERBB2 FAM90A1 FANCC GPRASP1 GPRASP2 MAPK10 MAPK3 MBD3 NGFR NTAQ1 PRKACA PSMB1 PSMC1 RGS20 RGS6 SESTD1 TEX11 TFCP2 TRPC5 TXLNA UBE2I	9 interacting genes: DRD2 ENKUR ITPR3 MX1 NHERF1 STMN2 STMN3 TRPC1 TRPC4
Entrez ID		11075	7224
HPRD ID		09003	02273
Ensembl ID		ENSG00000104435	ENSG00000072315
Uniprot IDs		Q93045	Q9UL62
PDB IDs			6YSN 7D4P 7D4Q 7E4T 7WDB 7X6C 7X6I 8GVW 8GVX
Enriched GO Terms of Interacting Partners?		Cytosol Calcium Channel Complex Cytoplasm Response To Epidermal Growth Factor ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Phosphorylation Intracellular Signaling Cassette Phosphorylation Neuromuscular Junction MAP Kinase Activity	Inositol 1,4,5 Trisphosphate Binding Acid Secretion Inorganic Ion Homeostasis Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Calcium Ion Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Metal Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Gamma-aminobutyric Acid Transport Monoatomic Cation Transport Cation Channel Complex Microtubule Depolymerization Regulation Of Sequestering Of Calcium Ion Chemical Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Ion Channel Activity Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Calcium Ion Homeostasis Intracellular Chemical Homeostasis Protein Depolymerization Microtubule Polymerization Or Depolymerization Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Cellular Homeostasis Carboxylic Acid Transport Organic Acid Transport Homeostatic Process Inorganic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Structural Constituent Of Presynaptic Actin Cytoskeleton Renal Phosphate Ion Absorption Tubulin Binding Monoatomic Ion Transmembrane Transport Regulation Of Sodium Ion Transport Response To Metal Ion Microtubule-based Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Organic Anion Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Phenol-containing Compound Metabolic Process Apical Part Of Cell
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