EPHA5 and DUSP21

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		EPHA5	DUSP21
Description		EPH receptor A5	dual specificity phosphatase 21
Image			No pdb structure
GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Membrane Axon Dendrite Cell Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytoskeleton Cilium Membrane Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Hippocampus Development Positive Regulation Of CREB Transcription Factor Activity Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Flagellated Sperm Motility Peptidyl-tyrosine Dephosphorylation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 22174851) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Severe skin toxicity response to cetuximab in colorectal cancer ( 30557370) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		8 interacting genes: ATM DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 NEDD4	33 interacting genes: APP ATP23 BPIFA1 CPNE7 CTBP2 EPHA3 EPHA5 ERBB3 ERBB4 EYA2 FAAP20 GET4 GORASP2 IGF1R KLHL20 KRT33B KRTAP11-1 MAP2K5 MYO15B OIP5 POU4F3 PTK7 RFX6 RGS2 ROR1 ROR2 SUOX TEX11 TOX3 TRAF1 UBQLN2 USP2 ZMAT1
Entrez ID		2044	63904
HPRD ID		02474	06494
Ensembl ID		ENSG00000145242	ENSG00000189037
Uniprot IDs		A0A384MU00 B7ZKJ3 B7ZKW7 F8VP57 F8W9W0 P54756 Q59FT4	Q9H596
PDB IDs		2R2P 4ET7
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Side Of Membrane Neuron Projection Development Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Enzyme-linked Receptor Protein Signaling Pathway Transmembrane-ephrin Receptor Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cell-cell Signaling Signaling Cell Communication Protein Monoubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Synapse Organization Signal Transduction Regulation Of Anatomical Structure Morphogenesis Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Formation Of Structure Involved In A Symbiotic Process Protein K63-linked Ubiquitination Regulation Of Peptidyl-tyrosine Phosphorylation Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Regulation Of Neuron Projection Development Cell Surface Receptor Signaling Pathway Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Channel Inhibitor Activity Positive Regulation Of Intracellular Signal Transduction DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Notochord Formation Phosphothreonine Residue Binding Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Axonogenesis Peptidyl-serine Autophosphorylation Nuclear Receptor-mediated Corticosteroid Signaling Pathway Cellular Response To Radiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Neurotrophin TRKA Receptor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Neuregulin Receptor Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway GPI-linked Ephrin Receptor Activity Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Coreceptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Glial Cell Development Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Cellular Developmental Process Insulin Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Neuron Projection Guidance Axon Guidance ERBB2 Signaling Pathway Establishment Of Planar Polarity ATP Binding Epithelial Cell Differentiation Amyloid-beta Complex Apoptotic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Heart Development Cranial Nerve Development Establishment Of Planar Polarity Involved In Nephron Morphogenesis Insulin-like Growth Factor Receptor Signaling Pathway Wnt-protein Binding Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Sulfite Oxidase Activity Type II Interferon Binding Meiotic Gene Conversion
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