EPHA5

Description		EPH receptor A5
Image
GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Membrane Axon Dendrite Cell Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Hippocampus Development Positive Regulation Of CREB Transcription Factor Activity Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 22174851) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Severe skin toxicity response to cetuximab in colorectal cancer ( 30557370) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		8 interacting genes: ATM DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 NEDD4
Entrez ID		2044
HPRD ID		02474
Ensembl ID		ENSG00000145242
Uniprot IDs		A0A384MU00 B7ZKJ3 B7ZKW7 F8VP57 F8W9W0 P54756 Q59FT4
PDB IDs		2R2P 4ET7
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Side Of Membrane Neuron Projection Development Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Enzyme-linked Receptor Protein Signaling Pathway Transmembrane-ephrin Receptor Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cell-cell Signaling Signaling Cell Communication Protein Monoubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Synapse Organization Signal Transduction Regulation Of Anatomical Structure Morphogenesis Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Formation Of Structure Involved In A Symbiotic Process Protein K63-linked Ubiquitination Regulation Of Peptidyl-tyrosine Phosphorylation Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Regulation Of Neuron Projection Development Cell Surface Receptor Signaling Pathway Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Channel Inhibitor Activity Positive Regulation Of Intracellular Signal Transduction DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Notochord Formation Phosphothreonine Residue Binding Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Axonogenesis Peptidyl-serine Autophosphorylation Nuclear Receptor-mediated Corticosteroid Signaling Pathway Cellular Response To Radiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Neurotrophin TRKA Receptor Binding
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