EFNA4 and EPHA8

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EFNA4	EPHA8
Description		ephrin A4	EPH receptor A8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Side Of Membrane	Endosome Plasma Membrane Membrane Dendrite Early Endosome Membrane Cell Projection Neuron Projection
	Molecular Function	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Growth Factor Binding
	Biological Process	Cell-cell Signaling Axon Guidance Ephrin Receptor Signaling Pathway	Substrate-dependent Cell Migration Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Neuron Remodeling Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Adventurousness ( 30643258) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		10 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 MAP2K4 TMEM147 TRARG1	12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746
Entrez ID		1945	2046
HPRD ID		03224	01493
Ensembl ID		ENSG00000243364	ENSG00000070886
Uniprot IDs		P52798	P29322
PDB IDs			1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway GPI-linked Ephrin Receptor Activity Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Regulation Of GTPase Activity Cell Surface Receptor Signaling Pathway Dendrite ATP Binding Plasma Membrane Bounded Cell Projection Organization Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Cell Projection Organization Nucleotide Binding Transferase Activity Growth Factor Binding Positive Regulation Of Protein Localization To Plasma Membrane Nephric Duct Morphogenesis Plasma Membrane Regulation Of Catalytic Activity Positive Regulation Of Protein Localization To Cell Periphery Neuromuscular Junction Regulation Of Synapse Pruning Positive Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Protein Localization To Plasma Membrane Axonal Fasciculation Neuron Projection Fasciculation Regulation Of Cell Adhesion Regulation Of Protein Localization To Cell Periphery Cell Adhesion Signal Transduction Cell Migration Ephrin Receptor Binding Regulation Of Protein Localization To Membrane Regulation Of Cellular Localization System Development Cell Motility Protein Tyrosine Kinase Binding Nervous System Development Neuron Recognition Regulation Of Cell Adhesion Mediated By Integrin	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway ATP Binding Neuron Projection Guidance Axon Guidance Nucleotide Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Synapse Organization Side Of Membrane Signaling Receptor Binding Regulation Of Postsynapse Organization Synaptic Membrane Adhesion Regulation Of Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Dendritic Spine Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Organization Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Regulation Of Cell Morphogenesis Cellular Response To Glycine Response To Singlet Oxygen Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Modification Process Positive Regulation Of Synapse Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Nucleoside Triphosphate Adenylate Kinase Activity Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of Phosphate Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Proliferation Response To Glycine Nuclear Proteasome Complex DNA/RNA Helicase Activity Aspartyl-tRNA Aminoacylation
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