CMYA5 and IL6ST

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		CMYA5	IL6ST
Description		cardiomyopathy associated 5	interleukin 6 cytokine family signal transducer
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Sarcoplasmic Reticulum M Band Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Cell Body Membrane Raft Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function		Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Coreceptor Activity Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Interleukin-27 Receptor Activity Scaffold Protein Binding
	Biological Process		Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Cell Differentiation Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation
Pathways			Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Bone mineral content ( 31790847) Hepatitis B surface antigen seroclearance in chronic hepatitis B infection ( 29975729) Obesity ( 23818313) Toenail selenium levels ( 25343990)	Blood protein levels ( 30072576) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Type 1 diabetes ( 34127860)
Interacting Genes		10 interacting genes: CAPN3 CLIP4 DTNBP1 DYSF HSPB2 IL6ST MYBPC2 OPTN PKNOX1 SNAPIN	35 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 NEDD4L OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		202333	3572
HPRD ID		16728	02824
Ensembl ID		ENSG00000164309	ENSG00000134352
Uniprot IDs		Q8N3K9	A0A0A0N0L2 A0A0A0N0L5 A0A8V8TMJ9 A0A8V8TNI4 P40189 Q17RA0
PDB IDs			1BJ8 1BQU 1I1R 1P9M 1PVH 3L5H 3L5I 3L5J 7U7N 8D6A 8D74 8D7R 8D82 8D85 8DPS 8DPT 8DPU 8UPA 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Regulation Of Neurotransmitter Secretion Anterograde Synaptic Vesicle Transport BLOC-1 Complex Synaptic Vesicle Membrane Structural Constituent Of Muscle T-tubule Sarcomere Organization Vesicle Transport Along Microtubule Synaptic Vesicle Transport Anterograde Axonal Transport Melanosome Organization Pigment Granule Organization Regulation Of Synaptic Vesicle Exocytosis Calcium-dependent Self Proteolysis Monocyte Activation Involved In Immune Response Vesicle Cytoskeletal Trafficking Positive Regulation Of Late Endosome To Lysosome Transport Axon Cytoplasm Axonal Transport Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Actin Cytoskeleton Organization Response To Unfolded Protein Interleukin-27 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Cytoplasmic Vesicle Axo-dendritic Transport Organelle Transport Along Microtubule Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Organelle Organization Actin Filament-based Process Cytoskeleton Organization Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Oncostatin-M Receptor Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Establishment Of Vesicle Localization Actomyosin Structure Organization Sarcolemma Somatic Muscle Development Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Interleukin-11 Receptor Activity Oncostatin-M-mediated Signaling Pathway Interleukin-11 Binding Vesicle Localization Regulation Of Regulated Secretory Pathway	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process T-helper 17 Cell Lineage Commitment Regulation Of Cell Population Proliferation Ciliary Neurotrophic Factor-mediated Signaling Pathway Signal Transduction Interleukin-6-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway T-helper Cell Lineage Commitment Negative Regulation Of Apoptotic Process Interleukin-11-mediated Signaling Pathway Phosphotyrosine Residue Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Alpha-beta T Cell Lineage Commitment Positive Regulation Of Peptidyl-tyrosine Phosphorylation CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cell Adhesion Regulation Of MAPK Cascade Regulation Of Apoptotic Process T Cell Lineage Commitment Receptor Complex Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Ciliary Neurotrophic Factor Receptor Activity Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Regulation Of Defense Response Regulation Of Macromolecule Metabolic Process Cytokine Receptor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction
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