FCN1

Description		ficolin 1
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Symbiont Cell Surface Ficolin-1-rich Granule Lumen Serine-type Endopeptidase Complex
	Molecular Function	G Protein-coupled Receptor Binding Antigen Binding Signaling Receptor Binding Protein Binding Carbohydrate Binding Sialic Acid Binding Pattern Recognition Receptor Activity Metal Ion Binding Carbohydrate Derivative Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Complement Activation G Protein-coupled Receptor Signaling Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Positive Regulation Of Interleukin-8 Production Protein Localization To Cell Surface Recognition Of Apoptotic Cell Innate Immune Response Host-mediated Suppression Of Symbiont Invasion Protein Maturation Positive Regulation Of Opsonization
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Trans-epidermal water loss ( 28011148)
Novel Interacting Genes		1 novel interacting genes: TSC1
Interacting Genes		2 interacting genes: ELN TGFB1
Entrez ID		2219
HPRD ID		03153
Ensembl ID		ENSG00000085265
Uniprot IDs		O00602
PDB IDs		2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Cytoskeleton Organization Aortic Valve Morphogenesis Regulation Of Actin Filament-based Process Extracellular Matrix Assembly Regulation Of Cytoskeleton Organization Heart Valve Morphogenesis Myelination Tube Closure Axon Ensheathment Neural Tube Closure Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Tube Formation Cellular Response To Acetaldehyde Memory T Cell Differentiation Regulation Of Smooth Muscle Cell Proliferation T Cell Differentiation Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Organelle Organization Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Extracellular Structure Organization Regulation Of Actin Filament Organization Regulation Of Cell Population Proliferation Regulation Of Cellular Component Size Elastic Fiber Extracellular Matrix Organization System Process Circulatory System Process Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of MiRNA Processing Myofibroblast Differentiation Mononuclear Cell Differentiation Foam Cell Differentiation Bronchiole Development Lymphocyte Differentiation Macrophage Derived Foam Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Adaptive Immune Response Positive Regulation Of Exit From Mitosis Negative Regulation Of Skeletal Muscle Tissue Development Response To Decreased Oxygen Levels Frontal Suture Morphogenesis Mammary Gland Branching Involved In Thelarche Type III Transforming Growth Factor Beta Receptor Binding Tolerance Induction To Self Antigen T Cell Activation Positive Regulation Of Isotype Switching To IgA Isotypes
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