RABEPK and PIKFYVE

Number of citations of the paper that reports this interaction (PubMedID 14530284)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		RABEPK	PIKFYVE
Description		Rab9 effector protein with kelch motifs	phosphoinositide kinase, FYVE-type zinc finger containing
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Endosome Membrane Membrane Transport Vesicle Trans-Golgi Network Membrane	Golgi Membrane Endosome Cytosol Endosome Membrane Vesicle Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Membrane Raft
	Molecular Function	Protein Binding	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Metal Ion Binding Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity Protein Serine Kinase Activity
	Biological Process	Receptor-mediated Endocytosis Vesicle Docking Involved In Exocytosis	Protein Targeting To Membrane Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Intracellular Protein Localization Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Chemotaxis Melanosome Organization Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Retrograde Transport, Endosome To Golgi Phosphatidylinositol Metabolic Process Phagosome Maturation Phagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly
Pathways		Retrograde transport at the Trans-Golgi-Network	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases			Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
GWAS		Refractive error ( 32231278)	Adult asthma ( 27611488) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		8 interacting genes: GLUL PIKFYVE POR PRKRA RAB9A TMEM98 TRIM55 ZYX	6 interacting genes: APP CDK5 H3C1 MIR140 RABEPK VAC14
Entrez ID		10244	200576
HPRD ID		09337	17852
Ensembl ID		ENSG00000136933	ENSG00000115020
Uniprot IDs		A0A024R8A0 A0A0S2Z4Z5 Q7Z6M1	Q9Y2I7
PDB IDs			7K2V
Enriched GO Terms of Interacting Partners?		Glutamine Synthetase Activity Intracellular Ammonium Homeostasis Glutamine Biosynthetic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Enzyme Activator Activity Nitric Oxide Catabolic Process Organofluorine Metabolic Process Phagocytic Vesicle Phagocytic Vesicle Membrane Retrograde Transport, Endosome To Golgi Phosphatidylinositol 5-phosphate Metabolic Process 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity 1-phosphatidylinositol-3-phosphate 5-kinase Activity 1-phosphatidylinositol-5-kinase Activity Cytosolic Transport Myeloid Leukocyte Migration Regulation Of Protein Localization To Nucleus Positive Regulation Of Steroid Hormone Biosynthetic Process Peptidyl-serine Autophosphorylation	Acetylcholine Receptor Activator Activity Cellular Response To Amyloid-beta Response To Amyloid-beta Amyloid-beta Complex Growth Cone Lamellipodium Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Endocytosis Regulation Of Receptor Internalization Glial Cell Development Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration PAS Complex PTB Domain Binding Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Positive Regulation Of Programmed Cell Death Regulation Of Chemokine Production Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Growth Cone Regulation Of Receptor-mediated Endocytosis Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Vesicle-mediated Transport Perikaryon Import Into Cell Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Developmental Cell Growth Microglia Development Developmental Growth Involved In Morphogenesis Positive Regulation Of G Protein-coupled Receptor Internalization ErbB-2 Class Receptor Binding Protein Kinase 5 Complex Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Adult Behavior Regulation Of Interleukin-6 Production Axonogenesis Learning
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