NSMCE1 and MAGEF1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology, affinity chromatography technology)

		NSMCE1	MAGEF1
Description		NSE1 component of SMC5/6 complex	MAGE family member F1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Smc5-Smc6 Complex Mitotic Spindle Pole	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Chromatin Looping	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 31619474 31959851) Gut microbiota (bacterial taxa) ( 27723756) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954)	Cerebral amyloid deposition (PET imaging) ( 30361487) Nose size ( 27182965)
Interacting Genes		4 interacting genes: ERBB3 MAGEF1 UBC UBE2D2	6 interacting genes: MDFI MMS19 NSMCE1 PHF7 TRAIP TRIM27
Entrez ID		197370	64110
HPRD ID		17648	14348
Ensembl ID		ENSG00000169189	ENSG00000177383
Uniprot IDs		Q8WV22	Q9HAY2
PDB IDs		2CT0 5HVQ 5WY5
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Post-translational Protein Modification Neuregulin Receptor Activity Macromolecule Catabolic Process ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Proteolysis Schwann Cell Differentiation Ubiquitin Protein Ligase Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Negative Regulation Of Motor Neuron Apoptotic Process Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Endocardial Cushion Development Protein Modification Process Protein Tag Activity Protein Tyrosine Kinase Activator Activity Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Striated Muscle Tissue Development Catabolic Process ERBB2 Signaling Pathway Peripheral Nervous System Development Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Cranial Nerve Development Ubiquitin Conjugating Enzyme Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Striated Muscle Tissue Development Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Growth Factor Binding Regulation Of Muscle Organ Development Nerve Development Negative Regulation Of DNA Recombination	Ubiquitin Protein Ligase Activity Protein Sumoylation Ubiquitin-protein Transferase Activity Negative Regulation Of Type I Interferon Production DNA Repair Post-translational Protein Modification Zinc Ion Binding Regulation Of Type I Interferon Production Transferase Activity Protein Modification By Small Protein Conjugation DNA Metabolic Process DNA Damage Response Negative Regulation Of Osteoclast Proliferation Cytosolic [4Fe-4S] Assembly Targeting Complex MMXD Complex Phosphatidylinositol 3-kinase Inhibitor Activity Nucleus Protein-DNA Covalent Cross-linking Repair Nucleoplasm Smc5-Smc6 Complex Transcription Coactivator Activity Positive Regulation Of Actin Nucleation Transcription Factor TFIIH Holo Complex Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Negative Regulation Of Cytokine Production Negative Regulation Of Viral Transcription Negative Regulation Of Interferon-beta Production Chromatin Looping Suppression Of Viral Release By Host Arp2/3 Complex-mediated Actin Nucleation Regulation Of Viral Transcription SUMO Transferase Activity Retromer Complex
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