NSMCE1

Description		NSE1 component of SMC5/6 complex
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Smc5-Smc6 Complex Mitotic Spindle Pole
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Chromatin Looping
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 31619474 31959851) Gut microbiota (bacterial taxa) ( 27723756) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954)
Interacting Genes		4 interacting genes: ERBB3 MAGEF1 UBC UBE2D2
Entrez ID		197370
HPRD ID		17648
Ensembl ID		ENSG00000169189
Uniprot IDs		Q8WV22
PDB IDs		2CT0 5HVQ 5WY5
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Post-translational Protein Modification Neuregulin Receptor Activity Macromolecule Catabolic Process ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Proteolysis Schwann Cell Differentiation Ubiquitin Protein Ligase Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Negative Regulation Of Motor Neuron Apoptotic Process Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Endocardial Cushion Development Protein Modification Process Protein Tag Activity Protein Tyrosine Kinase Activator Activity Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Striated Muscle Tissue Development Catabolic Process ERBB2 Signaling Pathway Peripheral Nervous System Development Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Cranial Nerve Development Ubiquitin Conjugating Enzyme Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Striated Muscle Tissue Development Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Growth Factor Binding Regulation Of Muscle Organ Development Nerve Development Negative Regulation Of DNA Recombination
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