METTL15 and MSRB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		METTL15	MSRB3
Description		methyltransferase 15, mitochondrial 12S rRNA N4-cytidine	methionine sulfoxide reductase B3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity RRNA (cytosine-N4-)-methyltransferase Activity	Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity Metal Ion Binding
	Biological Process	Methylation RRNA Base Methylation	Response To Oxidative Stress Protein Repair
Pathways			Protein repair
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Body size at age 10 ( 32376654) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Childhood body mass index ( 33045005) Chronotype ( 30696823) Daytime nap ( 33568662) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 31959993) Major depressive disorder (MTAG) ( 33479212) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Type 2 diabetes (adjusted for BMI) ( 30297969)	A body shape index ( 34021172) Antisaccade task score ( 31596458) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical volume ( 32963231) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		14 interacting genes: CIDEC CSTF2 FANCL GLYCTK HOXC8 MAPKBP1 MSRB3 NEK6 PEF1 PROP1 SPAG8 TRIP13 USHBP1 VAC14	31 interacting genes: ASB13 BANP EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL SKIC8 TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 ZMYND12
Entrez ID		196074	253827
HPRD ID		08750	14785
Ensembl ID		ENSG00000169519	ENSG00000174099
Uniprot IDs		A6NJ78	Q8IXL7
PDB IDs		7PNX 7PNY 7PNZ 8IPI 8IPK 8IPL 8IPM 8QRL	6QA0
Enriched GO Terms of Interacting Partners?			Intermediate Filament Structural Constituent Of Skin Epidermis Structural Molecule Activity Intermediate Filament Organization Methyltransferase Activity Protein Modification Process Protein Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Methylation
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