EPHA6

Description		EPH receptor A6
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Ephrin Receptor Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494) Blood trace element (Zn levels) ( 23720494) Heel bone mineral density x serum urate levels interaction ( 34046847) Longevity ( 26912274) Obesity-related traits ( 23251661) Systolic blood pressure ( 29208002) Weight ( 28552196) White matter hyperintensity volume ( 33293549)
Interacting Genes		2 interacting genes: EFNA1 EFNA4
Entrez ID		285220
HPRD ID		13275
Ensembl ID		ENSG00000080224
Uniprot IDs		A0A0B4J1T8 B3KS12 Q9UF33
PDB IDs
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Side Of Membrane Neuron Projection Guidance Axon Guidance Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Notochord Formation Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Dendritic Spine Development Mitral Valve Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Cell-cell Signaling Cell Communication Regulation Of Thymocyte Apoptotic Process Signaling Transmembrane-ephrin Receptor Activity Positive Regulation Of Amyloid-beta Formation Atrioventricular Valve Morphogenesis Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Amide Metabolic Process Aortic Valve Morphogenesis Negative Regulation Of Lymphocyte Apoptotic Process Cell Projection Organization Regulation Of T Cell Apoptotic Process Regulation Of Dendritic Spine Morphogenesis Regulation Of Amyloid-beta Formation Negative Regulation Of Epithelial To Mesenchymal Transition Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Dendritic Spine Development Negative Regulation Of Leukocyte Apoptotic Process Heart Valve Morphogenesis Regulation Of Lymphocyte Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Amide Metabolic Process Epithelial To Mesenchymal Transition Mesenchymal Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Blood Vessel Endothelial Cell Migration
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