EEF2 and CCT2

Number of citations of the paper that reports this interaction (PMID 23190606)
1

Data Source:
BioGRID (pull down)

		EEF2	CCT2
Gene Name		eukaryotic translation elongation factor 2	chaperonin containing TCP1, subunit 2 (beta)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Plasma Membrane Membrane Aggresome Ribonucleoprotein Complex Extracellular Vesicular Exosome	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Activator Activity Protein Kinase Binding Poly(A) RNA Binding	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Unfolded Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Translation Translational Elongation Pathogenesis Gene Expression Positive Regulation Of Gene Expression Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Chaperone-mediated Protein Complex Assembly Toxin Transport
Pathways		Synthesis of diphthamide-EEF2 Uptake and actions of bacterial toxins Translation Post-translational protein modification Peptide chain elongation Eukaryotic Translation Elongation Gamma carboxylation, hypusine formation and arylsulfatase activation Uptake and function of diphtheria toxin	Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		16 interactors: CCT2 CDKN2A DISC1 EEF2K EEF2KMT HNRNPD MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B TP53 TRPM7 UCHL5	18 interactors: ACTA1 ACTB EEF2 ERLIN2 FCHSD2 HSP90AB1 HSP90B1 PRPF40A PSMC6 PSMD2 RPS3 SSSCA1 SUMO4 TUBA1B TUBB VAV2 VRK2 YWHAG
Entrez ID		1938	10576
HPRD ID		00561	06895
Ensembl ID		ENSG00000167658	ENSG00000166226
Uniprot IDs		B4DPU3 P13639	P78371
PDB IDs		3J3A
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Cell Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein RNA Catabolic Process Positive Regulation Of Cell Aging Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Growth Mitotic Nuclear Envelope Reassembly Apoptotic Process Cell Cycle Process Nuclear Envelope Reassembly Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Wnt Signaling Pathway Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Replicative Senescence Regulation Of Cell Growth Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of DNA Replication Cellular Response To Organic Substance Signaling Cell Communication Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of JAK-STAT Cascade Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Arrest Nuclear-transcribed MRNA Catabolic Process Cell Cycle MRNA Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Aromatic Compound Catabolic Process	Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Division Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cellular Protein Metabolic Process Cell Cycle Phase Transition Positive Regulation Of Transferase Activity Regulation Of Apoptotic Process Protein Folding Immune System Process Regulation Of Cell Death Cell Cycle Process Endocytosis Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stress Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Immune Response-regulating Signaling Pathway Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Modification-dependent Protein Catabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Stress Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Catalytic Activity Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Programmed Cell Death Response To Interleukin-4 Cellular Protein Catabolic Process Cell Death Death Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of DNA N-glycosylase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint 'de Novo' Posttranslational Protein Folding Protein Catabolic Process Phagocytosis
Tagcloud ?		4e acutely alleviation assembly bps consequence consequent dephosphorylation eif2b eif4e eif4f elongation glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts translation untranslated utrs	antral atresia atretic bga build categorized cattle cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis tgm2 transcriptomic ultimately
Tagcloud (Difference) ?		4e acutely alleviation assembly bps consequence consequent dephosphorylation eif2b eif4e eif4f elongation glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts translation untranslated utrs	antral atresia atretic bga build categorized cattle cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis tgm2 transcriptomic ultimately
Tagcloud (Intersection) ?