EEF1B2 and HARS1

Number of citations of the paper that reports this interaction (PubMedID 11829477)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		EEF1B2	HARS1
Description		eukaryotic translation elongation factor 1 beta 2	histidyl-tRNA synthetase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex	Cytoplasm Cytosol
	Molecular Function	Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Histidine-tRNA Ligase Activity ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Translation Translational Elongation Response To Ethanol	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation
Pathways		Eukaryotic Translation Elongation	Cytosolic tRNA aminoacylation
Drugs			Histidine
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		15 interacting genes: AARS1 APP CEBPA CSNK2A1 CSNK2A2 DRD3 EEF1G HARS1 SPRYD4 TIMP1 TPT1 ULK2 USP7 VHL WBP2	10 interacting genes: EEF1B2 EEF1G MTNR1B OGT PSMC5 RPL5 TARS1 TNIK TTC3 WEE2-AS1
Entrez ID		1933	3035
HPRD ID		02804	00827
Ensembl ID		ENSG00000114942	ENSG00000170445
Uniprot IDs		P24534	B4DDD8 B4E1C5 P12081
PDB IDs		1B64 5DQS	1X59 2LW7 4G84 4G85 4PHC 4X5O 5W6M 6O76 8YOR 8YP1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Proteolysis Regulation Of Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Collateral Sprouting Regulation Of Neurotransmitter Uptake Regulation Of Signal Transduction By P53 Class Mediator Protein Serine/threonine Kinase Binding Regulation Of Protein Metabolic Process Regeneration Regulation Of Membrane Protein Ectodomain Proteolysis Signal Transduction PcG Protein Complex Cellular Response To Stress Amyloid Fibril Formation Protein Metabolic Process Cytosol TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity DNA-binding Transcription Factor Binding TRNA Aminoacylation Response To Stress Macromolecule Metabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity	Translation Protein Metabolic Process Translation Elongation Factor Activity Translational Elongation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nuclear Proteasome Complex Regulation Of Proteolysis Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Eukaryotic Translation Elongation Factor 1 Complex Cytosol Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Proteasome-activating Activity Cytosolic Proteasome Complex Thyrotropin-releasing Hormone Receptor Binding Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Proteolysis Cytoplasmic Translation Positive Regulation Of Translation Negative Regulation Of Protein Neddylation Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Microvillus Assembly Pre-mRNA 5'-splice Site Binding Extracellular Exosome Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Carbon Catabolite Regulation Of Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process MRNA 5'-splice Site Recognition
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