AGO3 and CXCR4

		AGO3	CXCR4
Description		argonaute RISC catalytic component 3	C-X-C motif chemokine receptor 4
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex Ribonucleoprotein Complex	Cytoplasm Lysosome Endosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving MiRNA-paired MRNA	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding
	Biological Process	MRNA Catabolic Process Regulation Of Translation Positive Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization RISC Complex Assembly Regulation Of Stem Cell Proliferation SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Response To Hypoxia Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Response To Virus Cell Migration Calcium-mediated Signaling Neurogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Cell Migration CXCL12-activated CXCR4 Signaling Pathway Myelin Maintenance Symbiont Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs			Baclofen Framycetin AMD-070 Plerixafor Ulocuplumab Ibalizumab MSX-122
Diseases			Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS			Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 19525953 31604244) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: ATP4B ATP6V0D2 BDNF CFTR SLC22A2	34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		192669	7852
HPRD ID		09558	01217
Ensembl ID		ENSG00000126070	ENSG00000121966
Uniprot IDs		B4E1P5 Q9H9G7	A0A0U3FJG0 A0A0U3GXA9 A0A8Q3WLL1 P61073
PDB IDs		5VM9 8VAJ	2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS 8GP3 8I0Q 8K3Z 8U4N 8U4O 8U4P 8U4Q 8U4R 8U4S 8U4T 8YU7 8ZPL 8ZPM 8ZPN
Enriched GO Terms of Interacting Partners?		Regulation Of PH Apical Plasma Membrane Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Transmembrane Transport Export Across Plasma Membrane Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Early Endosome Regulation Of Cellular PH Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Intracellular PH C-X-C Motif Chemokine 12 Receptor Activity Monoatomic Ion Homeostasis Cellular Homeostasis Import Across Plasma Membrane Inorganic Ion Transmembrane Transport P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Intracellular Chemical Homeostasis Proton Transmembrane Transport Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Organic Hydroxy Compound Transport Positive Regulation Of Monoatomic Anion Transport Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Amine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Plasma Membrane Proton-transporting V-type ATPase Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Nerve Growth Factor Receptor Binding Endosome Transepithelial Water Transport Spermidine Transport Thiamine Transmembrane Transporter Activity	Regulation Of Cell-cell Adhesion Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Regulation Of Defense Response Positive Regulation Of T Cell Activation Response To Stress Defense Response Positive Regulation Of Immune System Process Interleukin-9-mediated Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Response To Other Organism Cell Activation Immune System Process Negative Regulation Of Leukocyte Cell-cell Adhesion Response To External Biotic Stimulus Regulation Of Cytokine Production Interleukin-15-mediated Signaling Pathway Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Cell Migration Regulation Of Leukocyte Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Activation Leukocyte Mediated Cytotoxicity T Cell Activation Negative Regulation Of T Cell Activation Positive Regulation Of Immune Response Regulation Of Developmental Process Interleukin-6-mediated Signaling Pathway Regulation Of Multicellular Organismal Process
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