PHC1 and PCGF2

Number of citations of the paper that reports this interaction (PMID 23523425)
2

Data Source:
BioGRID (two hybrid)

		PHC1	PCGF2
Gene Name		polyhomeotic homolog 1 (Drosophila)	polycomb group ring finger 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Chromatin Binding Zinc Ion Binding	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Multicellular Organismal Development Histone Ubiquitination Cellular Response To Retinoic Acid	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Anterior/posterior Pattern Specification Protein Ubiquitination Histone Acetylation Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: BMI1 GMNN HSPA8 PCGF2 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 SCMH1 SFMBT1 SIAH1 SP100 SUMO1 SUMO1P1 UBE2I ZCCHC7	23 interactors: ABHD6 CBX6 CBX7 CBX8 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		1911	7703
HPRD ID		16009	10621
Ensembl ID		ENSG00000111752	ENSG00000056661
Uniprot IDs		B4DF21 J3KQH6 P78364 Q6GMQ3 Q6N083	P35227
PDB IDs		2L8E
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Chromatin Modification Chromatin Organization Regulation Of Metabolic Process Anterior/posterior Pattern Specification Peptidyl-lysine Modification Protein Sumoylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Ubiquitination Histone Ubiquitination Regulation Of RNA Metabolic Process Chromosome Organization Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Cellular Protein Modification Process Pattern Specification Process Cellular Protein Metabolic Process Developmental Process Regulation Of Signal Transduction Histone H2A Monoubiquitination Histone H2A Ubiquitination Regulation Of Signaling Organelle Organization RNA Metabolic Process Histone Monoubiquitination Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Protein Metabolic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cell Division Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process	Histone Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Chromatin Modification Chromatin Organization Protein Polyubiquitination Histone Modification Chromosome Organization Protein K48-linked Ubiquitination Protein Monoubiquitination Histone H2A Monoubiquitination Cellular Protein Modification Process Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Histone Monoubiquitination Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Sterol Regulatory Element Binding Protein Import Into Nucleus RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Anterior/posterior Pattern Specification Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Catabolic Process Regulation Of Gene Expression Protein Linear Polyubiquitination Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Tagcloud ?		bmi1a bmi1b cbx2 cbx4 cbx6a cbx6b cbx7a cbx7b cbx8a cbx8b combs enormous orthologs pcgf1 pcgf5a pcgf5b pcgf6 phc2a phc2b phc3 polyhomeotic prc1 psc ring1 rnf2 sce syntenies syntheses trimethylates	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Difference) ?		bmi1a bmi1b cbx2 cbx4 cbx6a cbx6b cbx7a cbx7b cbx8a cbx8b combs enormous orthologs pcgf1 pcgf5a pcgf5b pcgf6 phc2a phc2b phc3 polyhomeotic prc1 psc ring1 rnf2 sce syntenies syntheses trimethylates	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Intersection) ?