DSC2 and DSC3

		DSC2	DSC3
Description		desmocollin 2	desmocollin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Endoplasmic Reticulum Plasma Membrane Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cytoplasmic Vesicle Extracellular Exosome Anchoring Junction	Cornified Envelope Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Cell Junction Desmosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Calcium Ion Binding Gamma-catenin Binding Metal Ion Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cellular Response To Starvation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of P38MAPK Cascade	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Stabilization Cell-cell Adhesion
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Hypotrichosis and recurrent skin vesicles
GWAS		Blood protein levels ( 30072576) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483) Response to immune checkpoint inhibitors in melanoma (immune-related adverse events) ( 33409738)	Bronchopulmonary dysplasia ( 23897914) Hand grip strength (Mahalanobis distance) ( 32235003) Metabolite levels ( 31628463) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Supraventricular ectopy ( 29618737) Type 2 diabetes ( 31049640)
Interacting Genes		6 interacting genes: CLK1 DSG1 DSG2 JUP PKP2 PKP3	5 interacting genes: CTNNB1 JUP PKP3 PKP4 UCHL5
Entrez ID		1824	1825
HPRD ID		00512	02604
Ensembl ID		ENSG00000134755	ENSG00000134762
Uniprot IDs		A0A3B3ISU0 A0AAQ5BGT5 Q02487	Q14574
PDB IDs		5ERP 5J5J 7A7D
Enriched GO Terms of Interacting Partners?		Desmosome Cornified Envelope Desmosome Organization Cell-cell Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Assembly Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Cell Junction Cell Junction Organization Homotypic Cell-cell Adhesion Cell Adhesion Regulation Of Cardiac Muscle Contraction Cell Junction Assembly Gamma-catenin Binding Cell Adhesion Molecule Binding Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Epithelial Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Regulation Of Muscle Contraction Maternal Process Involved In Female Pregnancy Response To Progesterone Protein Localization To Plasma Membrane Adherens Junction Regulation Of Heart Contraction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cytoplasm Cellular Component Assembly Regulation Of System Process Protein Localization To Cell Periphery Calcium Ion Binding Regulation Of Muscle System Process Regulation Of Blood Circulation Purkinje Myocyte Development	Desmosome Adherens Junction Cornified Envelope Alpha-catenin Binding Cell-cell Junction Assembly Anchoring Junction Cell-cell Junction Organization Cell-cell Adhesion Catenin-TCF7L2 Complex Intercalated Disc Cell-cell Junction Cell Junction Cellular Response To Indole-3-methanol Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cell Junction Assembly Response To Indole-3-methanol Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Cadherin Binding Cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Cell Junction Organization Epithelial Cell-cell Adhesion Catenin Complex Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Midbrain Development Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Regulation Of Cell Adhesion Cardiac Conduction Skin Development Regulation Of Action Potential Homotypic Cell-cell Adhesion Positive Regulation Of Telomere Maintenance Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Gamma-catenin-TCF7L2 Complex Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction Regulation Of Embryonic Development Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex
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