CARS1 and PTP4A2

Number of citations: 81 (PubMedID 36300783)
Data Source: BioGRID (pull down)

		CARS1	PTP4A2
Name		cysteinyl-tRNA synthetase 1	protein tyrosine phosphatase 4A2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Ligase Activity Cysteine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Cysteinyl-tRNA Aminoacylation	None
Pathways		Cytosolic tRNA aminoacylation Signaling by ALK fusions and activated point mutants	RAB geranylgeranylation
Drugs		Cysteine	None
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Body mass index ( 26426971 )
Novel Interactors		1 novel interactors: DRD4	None recorded
Interacting Genes		7 interacting genes: APP EEF1G PTP4A2 RNF10 SUMO2 TRIM55 TRIM63	13 interacting genes: AKAP8L ATF7 CARS1 CNNM1 CNNM3 DHX15 DUSP22 EWSR1 HSP90AA1 HSP90AB1 MPO RABGGTB WIPF2
Entrez ID		833	8073
HPRD ID		00464	03348
Ensembl ID		ENSG00000110619	ENSG00000184007
Uniprot IDs		B4DKY1 B4DPV7 P49589	Q12974
PDB IDs		Not available	5K22 5K23 5K25 6WUR
GO Terms Enriched among Interactors		Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Postsynapse Protein Metabolic Process Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Neurotransmitter Uptake Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Response To Interleukin-1 Adult Locomotory Behavior Regulation Of Purine Nucleotide Metabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Response To Other Organism Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Adult Behavior Cellular Response To Norepinephrine Stimulus Defense Response Response To External Biotic Stimulus Regulation Of System Process Growth Factor Receptor Binding	Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Magnesium Ion Homeostasis Axonal Growth Cone Chaperone-mediated Protein Complex Assembly RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Telomere Maintenance Via Telomerase Histone Deacetylase Binding Disordered Domain Specific Binding DNA Polymerase Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Tyrosine Kinase Binding Tau Protein Binding CTP Binding DATP Binding Cellular Response To Heat Hypochlorous Acid Biosynthetic Process Protein Folding Chaperone Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation Double-stranded RNA Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Response To Gold Nanoparticle U2-type Post-mRNA Release Spliceosomal Complex Response To Alkaloid DNA Biosynthetic Process Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding Chromosome Organization Response To Heat Neuronal Cell Body Response To Transition Metal Nanoparticle Leading Edge Of Lamellipodium ATP Hydrolysis Activity Telomere Maintenance Melanosome Phagocytic Vesicle Lumen Rab-protein Geranylgeranyltransferase Complex