DPYS and DPYSL5

Number of citations of the paper that reports this interaction (PMID 10956643)
20

Data Source:
HPRD (in vivo, two hybrid)

		DPYS	DPYSL5
Gene Name		dihydropyrimidinase	dihydropyrimidinase-like 5
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Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Cytosol Dendrite Neuronal Cell Body
	Molecular Function	Uracil Binding Thymine Binding Dihydropyrimidinase Activity Zinc Ion Binding Amino Acid Binding Phosphoprotein Binding	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process	Pyrimidine Nucleobase Metabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Beta-alanine Metabolic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Catabolic Process Protein Homotetramerization Nucleobase-containing Small Molecule Metabolic Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance
Pathways		Pyrimidine catabolism Pyrimidine metabolism Metabolism of nucleotides	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS			Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661)
Protein-Protein Interactions		1 interactors: DPYSL5	8 interactors: APPL1 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5
Entrez ID		1807	56896
HPRD ID		01960	10522
Ensembl ID		ENSG00000147647	ENSG00000157851
Uniprot IDs		Q14117	Q9BPU6
PDB IDs		2VR2	4B90 4B91 4B92
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process	Pyrimidine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Folding In Endoplasmic Reticulum Nervous System Development Small Molecule Metabolic Process Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Neuron Differentiation Cerebellum Structural Organization Uracil Catabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Beta-alanine Metabolic Process Uracil Metabolic Process Thymine Metabolic Process Thymine Catabolic Process Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Neurogenesis Positive Regulation Of Glutamate Secretion TRNA Aminoacylation For Mitochondrial Protein Translation Cell Development Regulation Of Cell Development Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Asparaginyl-tRNA Aminoacylation Protein Homooligomerization ER Overload Response
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