DPYS

Name	dihydropyrimidinase
Structure
Interactors	2 interactors: APPBP2 DPYSL5
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Identical Protein Binding Metal Ion Binding Phosphoprotein Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process CMP Catabolic Process DCMP Catabolic Process UMP Catabolic Process DUMP Catabolic Process
Pathways	Pyrimidine catabolism
Diseases	Dihydropyrimidinase deficiency; Dihydropyrimidinuria
GWAS	Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821 ) Hallux valgus ( 32131869 ) Irritable mood ( 29500382 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Salivary metabolite levels ( 31960908 )
Entrez ID	1807
HPRD ID	01960
Ensembl ID	ENSG00000147647
Uniprot IDs	Q14117
PDB IDs	2VR2
GO Terms Enriched among Interactors ?	Negative Regulation Of Dendrite Morphogenesis Pyrimidine Nucleobase Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Dihydropyrimidinase Activity Cul2-RING Ubiquitin Ligase Complex Pyrimidine Nucleobase Metabolic Process Pyrimidine-containing Compound Catabolic Process Microtubule Associated Complex