DOCK1 and C10orf90

		DOCK1	C10orf90
Description		dedicator of cytokinesis 1	chromosome 10 open reading frame 90
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Actin Cytoskeleton
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding	Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Myoblast Fusion Positive Regulation Of Epithelial Cell Migration Cell Migration Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Protein Polyubiquitination Protein Ubiquitination Regulation Of Centriole Replication Protein Stabilization
Pathways		Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)	Age-related hearing impairment ( 34108613) Airway wall thickness ( 25517131) Early spontaneous preterm birth ( 31194736) Gestational age at birth (child effect) ( 31194736) Metabolite levels (MHPG) ( 23319000) Resistance to Mycobacterium tuberculosis infection ( 33661925) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Sitting height ratio ( 25865494)
Interacting Genes		11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2	3 interacting genes: GSK3B MTNR1A TP53
Entrez ID		1793	118611
HPRD ID		03240	16587
Ensembl ID		ENSG00000150760	ENSG00000154493
Uniprot IDs		A0A096LNH6 A0A2X0U2H5 B2RUU3 Q14185	Q96M02 S4R3N7
PDB IDs		3L4C
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Rac Protein Signal Transduction Actin Filament Organization Actin Cytoskeleton Organization Cell Chemotaxis Actin Filament-based Process Cell Motility Regulation Of Cellular Component Organization Supramolecular Fiber Organization Lamellipodium Assembly Regulation Of Postsynapse Assembly Lamellipodium Organization Chemotaxis Cell Migration Regulation Of Actin Cytoskeleton Organization Locomotion Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Receptor Tyrosine Kinase Binding Positive Regulation Of Receptor Clustering Endocytosis Postsynapse Positive Regulation Of Protein Localization To Membrane Response To Hepatocyte Growth Factor Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Receptor Clustering Regulation Of Cytoskeleton Organization Actin Cytoskeleton Glutamatergic Synapse Regulation Of Bicellular Tight Junction Assembly Protein Kinase A Regulatory Subunit Binding Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Import Into Cell Regulation Of Cell Shape Regulation Of Postsynapse Organization Regulation Of Ruffle Assembly Cytosol Neuron Migration Phagocytosis, Engulfment Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Synapse Assembly Regulation Of Protein Localization To Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Supramolecular Fiber Organization	ER Overload Response Circadian Rhythm Positive Regulation Of Mitochondrial Membrane Permeability Rhythmic Process Positive Regulation Of Membrane Permeability ER-nucleus Signaling Pathway Regulation Of Mitochondrial Membrane Permeability P53 Binding Regulation Of Membrane Permeability Positive Regulation Of Neuron Apoptotic Process Membrane Organization Regulation Of Circadian Rhythm Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Regulation Of Microtubule Anchoring At Centrosome Protease Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Positive Regulation Of Cell-substrate Adhesion Intracellular Signaling Cassette Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Generation Of Precursor Metabolites And Energy Viral Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Catalytic Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cell-substrate Adhesion Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Protein-containing Complex Assembly Melatonin Receptor Activity Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Postsynapse Response To Endoplasmic Reticulum Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?