DNTT and PRPF19

Number of citations of the paper that reports this interaction (PMID 12960389)
33

Data Source:
HPRD (in vitro, in vivo)

		DNTT	PRPF19
Gene Name		DNA nucleotidylexotransferase	pre-mRNA processing factor 19
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Particle Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity DNA Nucleotidylexotransferase Activity Metal Ion Binding	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Modification DNA Biosynthetic Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Double-strand Break Repair Via Nonhomologous End Joining RNA Splicing Lipid Biosynthetic Process Gene Expression Proteasomal Protein Catabolic Process Cellular Protein Localization Negative Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ABTB2 DNTTIP1 DNTTIP2 PCNA PRPF19 REL XRCC6	17 interactors: BCAS2 CDC5L DDX42 DNTT EGLN3 EXOC7 GSTK1 HSPB1 POLR2A PRCC PRPF8 PSMB4 RPA1 RPA2 RPA3 U2AF1 UBE2D3
Entrez ID		1791	27339
HPRD ID		08925	12214
Ensembl ID		ENSG00000107447	ENSG00000110107
Uniprot IDs		P04053	Q9UMS4
PDB IDs		2COE	4LG8
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Nonhomologous End Joining RNA Metabolic Process Telomere Maintenance Regulation Of RNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Generation Of Catalytic Spliceosome For First Transesterification Step Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Repair Cellular Nitrogen Compound Metabolic Process Leading Strand Elongation Double-strand Break Repair Cellular Hyperosmotic Salinity Response Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Cellular Response To DNA Damage Stimulus Macromolecule Biosynthetic Process Cellular Response To X-ray DNA Recombination Establishment Of Integrated Proviral Latency Transcription, DNA-templated Establishment Of Viral Latency Cellular Hyperosmotic Response Positive Regulation Of Astrocyte Differentiation Hyperosmotic Salinity Response DNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Translesion Synthesis Positive Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Salt Stress Positive Regulation Of Cellular Metabolic Process Spliceosomal Tri-snRNP Complex Assembly DNA Ligation Positive Regulation Of Cytokine Production Regulation Of Interleukin-12 Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Regulation Of Metabolic Process Positive Regulation Of Neurogenesis Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Inner Cell Mass Cell Proliferation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle	DNA Recombinase Assembly Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleotide-excision Repair Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Repair RNA Splicing Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing Mismatch Repair Base-excision Repair Cellular Response To Heat Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair MRNA Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition RNA Processing Cell Cycle Process DNA-dependent DNA Replication Response To Heat Heterocycle Metabolic Process Mitotic Cell Cycle Process DNA Catabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Double-strand Break Repair Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Protein-DNA Complex Assembly Response To Stress Cell Cycle
Tagcloud ?		angular anisotropy approaching behavior best characterization cm crystals dependence exceptionally field gap high independent investigated mobility observed purity quality simulation single structural structure suggest temperature transport v vacuum weak	beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?		angular anisotropy approaching behavior best characterization cm crystals dependence exceptionally field gap high independent investigated mobility observed purity quality simulation single structural structure suggest temperature transport v vacuum weak	beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?