DNMT1 and DNASE2

		DNMT1	DNASE2
Description		DNA methyltransferase 1	deoxyribonuclease 2, lysosomal
Image			No pdb structure
GO Annotations	Cellular Component	Heterochromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin Mitochondrion Germ Cell Nucleus	Lysosome Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding LncRNA Binding Promoter-specific Chromatin Binding	DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Deoxyribonuclease II Activity Protein Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Cell Population Proliferation Epigenetic Programming Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Cellular Response To Amino Acid Stimulus Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Bisphenol A Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	DNA Metabolic Process DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Enucleate Erythrocyte Differentiation Regulation Of Immune Response
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation STAT3 nuclear events downstream of ALK signaling Defective pyroptosis Nuclear events stimulated by ALK signaling in cancer	Lysosome Vesicle Biogenesis
Drugs		Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Clozapine-induced agranulocytosis ( 25187353) Immature fraction of reticulocytes ( 27863252) Mean corpuscular volume ( 29403010) Red cell distribution width ( 28957414)
Interacting Genes		53 interacting genes: AKT1 BAZ2A BRAP CBX1 CEBPA CSNK2B DAXX DCAF5 DMAP1 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ENSA EZH2 FBP1 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 LCOR MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SNHG6 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB UBC YWHAQ	1 interacting genes: XRN1
Entrez ID		1786	1777
HPRD ID		00532	00531
Ensembl ID		ENSG00000130816	ENSG00000105612
Uniprot IDs		I6L9H2 P26358 Q59FP7	O00115
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A 6L1F 6X9I 6X9J 6X9K 7SFC 7SFD 7SFE 7SFF 7SFG 7XI9 7XIB 8V9U 8XQC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Chromatin Remodeling Nucleoplasm Heterochromatin Formation Transcription Corepressor Activity Chromatin Binding Epigenetic Regulation Of Gene Expression Nucleus Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex Cellular Response To Stress Facultative Heterochromatin Formation DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription Corepressor Binding Enzyme Binding Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Rhythmic Process DNA-binding Transcription Factor Binding Cellular Response To Xenobiotic Stimulus Regulation Of Proteolysis Epigenetic Programming Of Gene Expression DNA Binding Macromolecule Metabolic Process Response To Lipid Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Protein Tag Activity	Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Puromycin Cellular Response To Cycloheximide DNA-methyltransferase Activity Germ Cell Nucleus DNA (cytosine-5-)-methyltransferase Activity Regulation Of Phenotypic Switching Cellular Response To Bisphenol A Response To Cycloheximide 5'-3' RNA Exonuclease Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Response To Bisphenol A G-quadruplex RNA Binding G-quadruplex DNA Binding 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Female Germ Cell Nucleus Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Histone MRNA Catabolic Process RRNA Catabolic Process Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Differentiation Cellular Response To Oxygen-containing Compound Telomerase RNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Histone MRNA Metabolic Process Replication Fork LncRNA Binding Methyl-CpG Binding Pericentric Heterochromatin Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Epigenetic Programming Of Gene Expression Regulation Of Smooth Muscle Cell Apoptotic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Nuclear RNA Surveillance Negative Regulation Of Telomere Maintenance RNA Surveillance Response To Testosterone Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Telomere Maintenance Via Telomerase Regulation Of Smooth Muscle Cell Differentiation Exonuclease Activity RNA Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Heterochromatin
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