DHFR and HSPD1

Number of citations of the paper that reports this interaction (PMID 8559246)
72

Data Source:
BioGRID (pull down, biochemical)
HPRD (in vitro)

		DHFR	HSPD1
Gene Name		dihydrofolate reductase	heat shock 60kDa protein 1 (chaperonin)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytosol	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Coated Pit Cell Surface Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Coated Vesicle Secretory Granule Protein Complex Lipopolysaccharide Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	MRNA Binding Dihydrofolate Reductase Activity Drug Binding NADP Binding	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Glycine Biosynthetic Process One-carbon Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nucleotide Biosynthetic Process Response To Methotrexate Small Molecule Metabolic Process Nitric Oxide Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Regulation Of Nitric-oxide Synthase Activity Oxidation-reduction Process	B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Viral Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of nitric oxide G1/S Transition G1/S-Specific Transcription Metabolism of folate and pterines eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Mitotic G1-G1/S phases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency E2F mediated regulation of DNA replication Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Cell Cycle, Mitotic Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism	Mitochondrial protein import
Drugs		NADH Pyrimethamine Trimethoprim Methotrexate Pemetrexed Proguanil Trimetrexate 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine 2,4-Diamino-6-[N-(2\',5\'-Dimethoxybenzyl)-N-Methylamino]Quinazoline 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine 2,4-Diamino-6-[N-(3\',4\',5\'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Sri-9662 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium Sri-9439 2\'-Monophosphoadenosine 5\'-Diphosphoribose 6-(2,5-Dimethoxy-Benzyl)-5-Methyl-Pyrido[2,3-D]Pyrimidine-2,4-Diamine Biopterin 2,4-Diamino-6-[N-(3\',5\'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Pralatrexate 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-4\'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-3\',5\'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-2\',6\'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AMFR ASGR1 FKBP1A GKAP1 HSPD1 MDM2 THBS1 TOMM20 TP53 UBC	40 interactors: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FHIT HIST2H2BE HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 NOTCH2NL NR3C1 PLG PPP2R1A PPP2R1B PRKACA PRNP RASA1 RGS20 SAMD3 SIRT3 SUMO4 TLR1 TMCC2 YWHAG
Entrez ID		1719	3329
HPRD ID		00519	00318
Ensembl ID		ENSG00000228716	ENSG00000144381
Uniprot IDs		B0YJ76 B4DDD2 P00374	P10809
PDB IDs		1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3B 2W3M 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW 3GI2 3GYF 3L3R 3N0H 3NTZ 3NU0 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZD 3OAF 3S3V 3S7A 4DDR 4M6J 4M6K 4M6L
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Hypoxia Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Negative Regulation Of Catalytic Activity Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macrophage Activation Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Lymphocyte Proliferation Mononuclear Cell Proliferation Response To Organic Substance Negative Regulation Of Hydrolase Activity Leukocyte Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Unfolded Protein Regulation Of Cell Cycle G1/S Phase Transition Apoptotic Process Negative Regulation Of Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Magnesium Ion Programmed Cell Death DNA Damage Checkpoint Protein Refolding Protein Complex Assembly Cell Death Death Mitotic Cell Cycle Checkpoint	Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Cell Death Regulation Of Cell Death Death Apoptotic Process Positive Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Response To Organic Substance Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Response To Stimulus Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Cellular Protein Metabolic Process Cell Communication Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Phosphorylation Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intracellular Signal Transduction Cell Differentiation Cell Cycle Process Negative Regulation Of Phosphorylation Response To Stress Mitotic Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Regulation Of Cell Adhesion Positive Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Neuron Death Regulation Of Neuron Death Response To Organic Cyclic Compound
Tagcloud ?		attains becomes charged combine crossed dehydrofolate evolutionarily export import imported inner inserted intermembrane lengths moieties oxa1p pairwise peptidase polytopic postulate poxa1p preproteins presequence segments sorting stop stretches tm translocated	5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Difference) ?		attains becomes charged combine crossed dehydrofolate evolutionarily export import imported inner inserted intermembrane lengths moieties oxa1p pairwise peptidase polytopic postulate poxa1p preproteins presequence segments sorting stop stretches tm translocated	5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Intersection) ?