ZCCHC12 and RNF40

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZCCHC12	RNF40
Description		zinc finger CCHC-type containing 12	ring finger protein 40
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane HULC Complex
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		27 interacting genes: ABHD5 APP APPBP2 ATP6V0C CD207 FADD FATE1 KPNA3 LMO1 MAGEA11 MCRS1 MX1 PNMA1 PRMT1 RNF40 RUSF1 SPOP STX2 SUMO1 SUMO2 SUMO3 TADA2A TFCP2 TMEM43 TMEM79 TNF UBE2I	27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DUSP29 EEF1D H2AC4 H2BC3 ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL PKNOX1 RB1 RPA1 RPA2 TRIM51 UBE2A UBE2B UBE2D2 UBE2I UBE2L6 ZCCHC12 ZNF451
Entrez ID		170261	9810
HPRD ID		06616	07411
Ensembl ID		ENSG00000174460	ENSG00000103549
Uniprot IDs		Q6PEW1	A8K6K1 O75150
PDB IDs			8GUI 8GUJ 8IEJ
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Tag Activity Transcription Factor Binding Ubiquitin Protein Ligase Binding Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Proteolysis Regulation Of Proteolysis PML Body Small Protein Activating Enzyme Binding Protein Modification By Small Protein Conjugation Necroptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type II Interferon Production Identical Protein Binding Post-translational Protein Modification Nucleoplasm Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Protein Catabolic Process Nuclear Pore Astrocyte Activation Negative Regulation Of DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Amyloid-beta Clearance SUMO Transferase Activity Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Storage Negative Regulation Of Blood Circulation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of MiRNA Transcription Regulation Of Type II Interferon Production Regulation Of RNA Metabolic Process Microglial Cell Activation Defense Response To Virus Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of JNK Cascade	Ubiquitin Conjugating Enzyme Activity Protein Localization To Chromosome PML Body Ubiquitin-like Protein Transferase Activity Chromosome, Telomeric Region Positive Regulation Of MRNA 3'-end Processing HULC Complex Chromatin Organization Nucleus Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Modification By Small Protein Conjugation Protein Polyubiquitination Telomere Localization Regulation Of MRNA 3'-end Processing G-rich Strand Telomeric DNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition DNA Replication Factor A Complex Chromosome Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Site Of Double-strand Break Chromatin Remodeling Telomere Maintenance Proteolysis Involved In Protein Catabolic Process Histone MRNA Metabolic Process Response To Radiation Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Site Of Double-strand Break Sperm Axoneme Assembly Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Mismatch Repair Telomere Organization DNA Repair MRNA 3'-end Processing Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Recombinational Repair Regulation Of DNA Recombination Positive Regulation Of RNA Binding
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