ZCCHC12 and TMEM43

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZCCHC12	TMEM43
Description		zinc finger CCHC-type containing 12	transmembrane protein 43
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process		Immune System Process Lipid Metabolic Process Innate Immune Response Nuclear Membrane Organization
Pathways
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549) Longevity ( 33657282)
Interacting Genes		27 interacting genes: ABHD5 APP APPBP2 ATP6V0C CD207 FADD FATE1 KPNA3 LMO1 MAGEA11 MCRS1 MX1 PNMA1 PRMT1 RNF40 RUSF1 SPOP STX2 SUMO1 SUMO2 SUMO3 TADA2A TFCP2 TMEM43 TMEM79 TNF UBE2I	16 interacting genes: APOA5 ARL13B CARD10 CISD2 FAM209A FDFT1 FGA FKBP8 GRAMD2B LMNA PCYT1B SCGB1A1 SIAH1 SYNDIG1 USP25 ZCCHC12
Entrez ID		170261	79188
HPRD ID		06616	15541
Ensembl ID		ENSG00000174460	ENSG00000170876
Uniprot IDs		Q6PEW1	A0A024R2F9 Q9BTV4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Tag Activity Transcription Factor Binding Ubiquitin Protein Ligase Binding Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Proteolysis Regulation Of Proteolysis PML Body Small Protein Activating Enzyme Binding Protein Modification By Small Protein Conjugation Necroptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type II Interferon Production Identical Protein Binding Post-translational Protein Modification Nucleoplasm Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Protein Catabolic Process Nuclear Pore Astrocyte Activation Negative Regulation Of DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Amyloid-beta Clearance SUMO Transferase Activity Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Storage Negative Regulation Of Blood Circulation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of MiRNA Transcription Regulation Of Type II Interferon Production Regulation Of RNA Metabolic Process Microglial Cell Activation Defense Response To Virus Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of JNK Cascade
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