CCR6 and CCL20

Number of citations of the paper that reports this interaction (PMID 9169459)
62

Data Source:
HPRD (in vivo, in vitro)

		CCR6	CCL20
Gene Name		chemokine (C-C motif) receptor 6	chemokine (C-C motif) ligand 20
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity	Protein Binding Chemokine Activity
	Biological Process	Dendritic Cell Chemotaxis Movement Of Cell Or Subcellular Component Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Innate Immune Response Chemokine-mediated Signaling Pathway	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Wound Healing Defense Response To Bacterium Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Chemotaxis Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of T Cell Migration
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Beta defensins Defensins G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 20570966 21102463) Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 20453841 20453842) Vitiligo ( 20526339)	Blood pressure ( 17903302) Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		4 interactors: CCL20 DEFB1 DEFB103B DEFB4A	3 interactors: CCR6 TGFB3 VCAN
Entrez ID		1235	6364
HPRD ID		03498	03571
Ensembl ID		ENSG00000112486	ENSG00000115009
Uniprot IDs		P51684	P78556
PDB IDs			1M8A 2HCI 2JYO
Enriched GO Terms of Interacting Partners?		Defense Response To Bacterium Response To Bacterium Response To Other Organism Response To Biotic Stimulus Immune Response Defense Response Response To External Stimulus Chemotaxis Immune System Process Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process Response To Stress Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria Locomotion Positive Regulation Of Antimicrobial Humoral Response Regulation Of Antimicrobial Humoral Response Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Defense Response To Bacterium Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cellular Response To Lipoteichoic Acid Positive Regulation Of Humoral Immune Response Innate Immune Response In Mucosa Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Antibacterial Humoral Response Antimicrobial Humoral Response Regulation Of Lymphocyte Migration Mucosal Immune Response Positive Regulation Of Interleukin-1 Production Response To Testosterone Response To Lipid Positive Regulation Of Immune System Process Regulation Of Humoral Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Acute Inflammatory Response G-protein Coupled Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Leukocyte Migration Regulation Of Immune System Process Regulation Of Cytokine Biosynthetic Process Regulation Of Leukocyte Migration Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Cell Chemotaxis	Detection Of Hypoxia Uterine Wall Breakdown Ossification Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Frontal Suture Morphogenesis Detection Of Oxygen Extracellular Matrix Organization Extracellular Structure Organization Embryonic Neurocranium Morphogenesis SMAD Protein Import Into Nucleus Dermatan Sulfate Biosynthetic Process Cranial Suture Morphogenesis Dermatan Sulfate Proteoglycan Biosynthetic Process Skeletal System Development Dermatan Sulfate Proteoglycan Metabolic Process Positive Regulation Of SMAD Protein Import Into Nucleus Dendritic Cell Chemotaxis Chondroitin Sulfate Catabolic Process Regulation Of SMAD Protein Import Into Nucleus Craniofacial Suture Morphogenesis Response To Laminar Fluid Shear Stress Chondroitin Sulfate Biosynthetic Process Dendritic Cell Migration Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Cell Motility Positive Regulation Of Filopodium Assembly Response To Fluid Shear Stress Face Morphogenesis Regulation Of Collagen Metabolic Process Positive Regulation Of Bone Mineralization Head Morphogenesis Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Regulation Of Filopodium Assembly Salivary Gland Development Negative Regulation Of DNA Replication Response To Progesterone Face Development Lung Alveolus Development Cellular Defense Response Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Proteoglycan Biosynthetic Process
Tagcloud ?		confounding conservation corresponded cxcr3 elicit eliminating epitopes hc hcs hyperconserved intragenus latent ltbi mtb mycobacteria naturally nonexposed nontuberculous ntm ntms opposite phenotypically reactivity recognize responded translated true unbiased unexpectedly	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Difference) ?		confounding conservation corresponded cxcr3 elicit eliminating epitopes hc hcs hyperconserved intragenus latent ltbi mtb mycobacteria naturally nonexposed nontuberculous ntm ntms opposite phenotypically reactivity recognize responded translated true unbiased unexpectedly	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Intersection) ?