CCR6 and CCL20

Number of citations of the paper that reports this interaction (PubMedID 9294137)
53

Data Source:
HPRD (in vitro, in vivo)

		CCR6	CCL20
Description		C-C motif chemokine receptor 6	C-C motif chemokine ligand 20
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Cytokine Activity Protein Binding Chemokine Activity CCR6 Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Calcium-mediated Signaling Killing Of Cells Of Another Organism Defense Response To Bacterium Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide T Cell Migration Thymocyte Migration Positive Regulation Of T Cell Migration
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 18587394 23850713 21102463 20570966) Graves' disease ( 22922229) Inflammatory bowel disease ( 23128233 27569725 28067908) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 32723749 24390342 23143596 20453841) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 27723757 20526339)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31959851 32296059 34103634) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Blood pressure ( 17903302) Crohn's disease ( 26192919) Eating disorders (purging via substances) ( 23568457) Inflammatory bowel disease ( 26192919) Primary biliary cholangitis ( 26394269) Ulcerative colitis ( 26192919)
Interacting Genes		5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1	11 interacting genes: CCL5 CCR6 CXCL11 CXCL12 CXCL17 CXCL5 MTDH PF4 TGFB3 VCAN XCL2
Entrez ID		1235	6364
HPRD ID		03498	03571
Ensembl ID		ENSG00000112486	ENSG00000115009
Uniprot IDs		P51684	P78556
PDB IDs		6WWZ	1M8A 2HCI 2JYO 5UR7 6WWZ 7T1E
Enriched GO Terms of Interacting Partners?		CCR6 Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Humoral Immune Response Defense Response To Gram-negative Bacterium Locomotion Defense Response To Bacterium Chemotaxis Golgi Lumen Defense Response To Other Organism Defense Response To Gram-positive Bacterium Defense Response To Symbiont Killing Of Cells Of Another Organism Response To Bacterium Chemoattractant Activity Cell Killing Cell Chemotaxis Response To Other Organism Positive Chemotaxis Immune Response Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Response To External Biotic Stimulus Defense Response Phosphatidylinositol-4,5-bisphosphate Binding Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Regulation Of Response To DNA Integrity Checkpoint Signaling Extracellular Space Cell Migration Flavin-dependent Sulfhydryl Oxidase Activity Thymocyte Migration Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Nuclear Speck Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse L-lysine Catabolic Process Negative Regulation Of Translational Elongation Cell Motility Thiol Oxidase Activity Splicing Factor Binding Immune System Process Lysine Catabolic Process Negative Regulation Of Centriole Replication Calcium-mediated Signaling Positive Regulation Of Gene Expression	Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Chemotaxis Locomotion Cytokine Activity Mononuclear Cell Migration Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Humoral Immune Response Cell Migration Antimicrobial Humoral Response Cell Motility Chemokine-mediated Signaling Pathway Extracellular Space CXCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Extracellular Region Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Monocyte Chemotaxis Myeloid Leukocyte Migration Regulation Of Monocyte Chemotaxis T Cell Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Immune Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Regulation Of T Cell Migration CXCR3 Chemokine Receptor Binding Cell Surface Receptor Signaling Pathway Defense Response Lymphocyte Migration Regulation Of Chemotaxis Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Inflammatory Response Granulocyte Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Chemokine Receptor Binding Positive Regulation Of Locomotion Granulocyte Migration Response To Other Organism Positive Regulation Of Calcium Ion Transport T Cell Chemotaxis
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