LINC01016 and EPRS1

Number of citations of the paper that reports this interaction (PubMedID 37550275)
32

Data Source:
BioGRID (unspecified method)

		LINC01016	EPRS1
Description		long intergenic non-protein coding RNA 1016	glutamyl-prolyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex
	Molecular Function		Nucleotide Binding RNA Binding Catalytic Activity Aminoacyl-tRNA Ligase Activity Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding GTPase Binding
	Biological Process		Translation Regulation Of Translation TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus TRNA Aminoacylation Cellular Response To Type II Interferon Regulation Of Long-chain Fatty Acid Import Into Cell
Pathways			Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Glutamic acid Proline 5'-O-(L-Prolylsulfamoyl)adenosine 5'-O-(L-Cysteinylsulfamoyl)adenosine 5'-O-(N-(Alanyl)sulfamoyl)adenosine
Diseases
GWAS		Alanine transaminase levels ( 29403010) Multisite chronic pain ( 33830993)
Interacting Genes		2 interacting genes: DHX9 EPRS1	93 interacting genes: AIMP2 ARL4D BTG3 CDC42 CEBPA DUS2 DUX4 EEF1D HSP90AA1 HUNK IARS1 LINC01016 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NELFCD PTEN RARS1 RNF10 SUMO2 SYNCRIP TAB1
Entrez ID		100507584	2058
HPRD ID			00703
Ensembl ID		ENSG00000249346	ENSG00000136628
Uniprot IDs			P07814
PDB IDs			1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6 7BBU 7F98 7F99 7F9A 7F9B 7F9C 7F9D 7OSY 7OSZ 7OT0 7OT1 7OT2 7OT3 7X09 7X1O 7Y1H 7Y1W 7Y28 7Y3S
Enriched GO Terms of Interacting Partners?		RNA Stem-loop Binding 3'-5' DNA/RNA Helicase Activity DNA-templated Viral Transcription Regulatory Region RNA Binding Proline-tRNA Ligase Activity Prolyl-tRNA Aminoacylation Triplex DNA Binding Glutamyl-tRNA Aminoacylation Glutamate-tRNA Ligase Activity Positive Regulation Of RNA Export From Nucleus Perichromatin Fibrils RISC Complex Binding Positive Regulation Of Viral Transcription Single-stranded 3'-5' DNA Helicase Activity Regulation Of Translation Viral Transcription Ribonucleoprotein Complex CRD-mediated MRNA Stability Complex Catalytic Activity, Acting On A Nucleic Acid GAIT Complex RISC-loading Complex Nucleoside Triphosphate Diphosphatase Activity Nuclear Stress Granule Protein Localization To Cytoplasmic Stress Granule 3'-5' RNA Helicase Activity Regulation Of Long-chain Fatty Acid Import Into Cell Importin-alpha Family Protein Binding Post-transcriptional Regulation Of Gene Expression SiRNA Binding RISC Complex Assembly Positive Regulation Of Interleukin-18 Production CRD-mediated MRNA Stabilization Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay 3'-5' DNA Helicase Activity Ribonucleoside Triphosphate Phosphatase Activity Regulation Of Interleukin-18 Production Sequence-specific MRNA Binding Cellular Response To Exogenous DsRNA DNA Replication Origin Binding Positive Regulation Of Cytoplasmic Translation Regulation Of RNA Export From Nucleus RNA Polymerase Binding DNA-templated Transcription Termination Regulation Of Viral Transcription Cellular Response To DsRNA Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Interferon-alpha Production RNA Polymerase II Complex Binding	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Metabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process
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