UBXN2A and UBXN6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		UBXN2A	UBXN6
Description		UBX domain protein 2A	UBX domain protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cis-Golgi Network Cytosol Dendrite Cell Projection Perikaryon	Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Centrosome Cytosol Cytoskeleton Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Acetylcholine Receptor Binding Ubiquitin Binding	Protein Binding ATPase Binding
	Biological Process	Autophagosome Assembly Golgi Organization Regulation Of Protein Ubiquitination Nuclear Membrane Reassembly Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Macromolecule Metabolic Process Membrane Fusion Negative Regulation Of ERAD Pathway Cellular Response To Leukemia Inhibitory Factor	Response To Stress Macroautophagy Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway ERAD Pathway
Pathways
Drugs
Diseases
GWAS		Chronotype ( 30696823) Diabetic retinopathy (all NPDR and PDR) ( 30487263) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Red cell distribution width ( 28957414 32888494) Regular attendance at a religious group ( 29970889) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Multiple sclerosis ( 31604244) Red blood cell count ( 32888494)
Interacting Genes		4 interacting genes: DBI DYDC2 PHAX UBXN6	21 interacting genes: APP DAZAP2 DERL1 FAM168A GSK3B MAGEA4 MCL1 NLGN3 OGT PLEKHB2 SMURF1 SUSD6 SVIP TNFAIP3 TRIM39 UBC UBXN10 UBXN2A UBXN2B VCP YOD1
Entrez ID		165324	80700
HPRD ID		10292	18253
Ensembl ID		ENSG00000173960	ENSG00000167671
Uniprot IDs		P68543	Q9BZV1
PDB IDs			6SAP 8FCL 8FCM 8FCN 8FCO 8FCP 8FCQ 8FCR 8FCT
Enriched GO Terms of Interacting Partners?		Protein-lipid Complex Benzodiazepine Receptor Binding Negative Regulation Of Protein Lipidation Long-chain Fatty Acyl-CoA Binding SnRNA Export From Nucleus MRNA Cap Binding Complex Binding Regulation Of Protein Lipidation Negative Regulation Of Lipoprotein Metabolic Process Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Lipoprotein Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Fatty-acyl-CoA Binding Positive Regulation Of Phospholipid Transport Toxic Substance Binding Set1C/COMPASS Complex Perinuclear Endoplasmic Reticulum	Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process ERAD Pathway Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding Regulation Of Protein Modification Process Response To Endoplasmic Reticulum Stress Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of ERAD Pathway Catabolic Process Derlin-1 Retrotranslocation Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Membrane Assembly Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Protein Localization Endoplasmic Reticulum Unfolded Protein Response Protein K11-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway
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