DCK and TFEC

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DCK	TFEC
Description		deoxycytidine kinase	transcription factor EC
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleotide Binding Deoxyadenosine Kinase Activity Deoxycytidine Kinase Activity Deoxyguanosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Deoxynucleoside Kinase Activity Protein Homodimerization Activity Cytidine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleotide Metabolic Process CMP Biosynthetic Process DAMP Salvage Carbohydrate Derivative Metabolic Process Nucleoside Phosphate Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Pyrimidine salvage Purine salvage	Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Fludarabine 2'-Deoxycytidine Elacytarabine
Diseases
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150)	Body mass index ( 28892062) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Intraocular pressure ( 29235454 29617998 29785010) Number of sexual partners ( 30643258) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Tonsillectomy ( 27182965 28928442)
Interacting Genes		7 interacting genes: ATM CRYAA DDX19B GOLM1 MED19 RXRG TFEC	11 interacting genes: DCK DEFB127 HNRNPA1 LPAR3 MITF NAPB SMCO4 TET2 TFE3 TFEB ZMAT2
Entrez ID		1633	22797
HPRD ID		00507	05294
Ensembl ID		ENSG00000156136	ENSG00000105967
Uniprot IDs		B4E0A5 F5CTF3 P27707	O14948
PDB IDs		1P5Z 1P60 1P61 1P62 2A2Z 2A30 2A7Q 2NO0 2NO1 2NO6 2NO7 2NO9 2NOA 2QRN 2QRO 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7 2ZI9 2ZIA 3HP1 3IPX 3IPY 3KFX 3MJR 3QEJ 3QEN 3QEO 4JLJ 4JLK 4JLM 4JLN 4KCG 4L5B 4Q18 4Q19 4Q1A 4Q1B 4Q1C 4Q1D 4Q1E 4Q1F 5MQJ 5MQL 5MQT 7ZI1 7ZI2 7ZI3 7ZI5 7ZI6 7ZI7 7ZI8 7ZI9 7ZIA 7ZIB 8OOJ
Enriched GO Terms of Interacting Partners?			Deoxyguanosine Kinase Activity Deoxynucleoside Kinase Activity Deoxyadenosine Kinase Activity Deoxycytidine Kinase Activity DAMP Salvage Telomeric Repeat-containing RNA Binding DNA Binding Protein Dimerization Activity Melanocyte Apoptotic Process Lysosomal Membrane Regulation Of Osteoclast Differentiation Lysosome Organization Humoral Immune Response Defense Response To Gram-negative Bacterium DNA 5-methylcytosine Dioxygenase Activity Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Cytidine Kinase Activity CMP Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lysophosphatidic Acid Receptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Myeloid Leukocyte Differentiation Cellular Response To Sodium Arsenite Lysosome
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