RHOXF1 and NPAS2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		RHOXF1	NPAS2
Gene Name		Rhox homeobox family, member 1	neuronal PAS domain protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Transcription Factor Complex Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Gamete Generation Sexual Reproduction Intracellular Steroid Hormone Receptor Signaling Pathway	Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Signal Transduction Central Nervous System Development Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Sleep/wake Cycle Cellular Lipid Metabolic Process Small Molecule Metabolic Process Locomotor Rhythm Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Redox State Negative Regulation Of Cell Death Regulation Of Response To DNA Damage Stimulus
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS			Creutzfeldt-Jakob disease (variant) ( 22137330)
Protein-Protein Interactions		2 interactors: NPAS2 VTN	19 interactors: ARNT2 ARNTL ARNTL2 CREBBP CRX EFS EP300 HESX1 HGS HSP90AA1 KAT2B NCOA3 RARA RASSF7 RHOXF1 RPL6 RXRA TRAF4 ZSCAN1
Entrez ID		158800	4862
HPRD ID		15954	09137
Ensembl ID		ENSG00000101883	ENSG00000170485
Uniprot IDs		Q8NHV9	A2I2P5 F5H027 Q99743
PDB IDs
Enriched GO Terms of Interacting Partners?		Circadian Sleep/wake Cycle Locomotor Rhythm Cell Adhesion Mediated By Integrin Response To Redox State Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Circadian Behavior Rhythmic Behavior Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Complement Activation Positive Regulation Of DNA Repair Positive Regulation Of Receptor-mediated Endocytosis Endodermal Cell Differentiation Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Wound Healing Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Endoderm Formation Negative Regulation Of Coagulation Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Protein Binding Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Circadian Regulation Of Gene Expression Endoderm Development Regulation Of Blood Coagulation Positive Regulation Of Endocytosis	RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression N-terminal Protein Amino Acid Acetylation Rhythmic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signal Transduction Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Communication Biosynthetic Process Cellular Nitrogen Compound Metabolic Process N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Histone Acetylation Regulation Of Cellular Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Circadian Rhythm Response To Stimulus Intracellular Receptor Signaling Pathway Embryo Development Cellular Response To Heat Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		aminomethyl aminophenyl ato benzamide carbonyl dac deacetylases decitabine demethylation deoxycytidine dimethylated dnmt dnmt1 dnmt3b entinostat hdacs homeobox homeodomain methyltransferases potencies pyridine rhox5 rhox6 rhox9 trioxide underlining ylmethoxy	additively bmal1 box circadian clock electrophoretic ems fold heme heterodimer homodimer kd kinetics luciferase maximal metabolite mixture mobility monoxide nad nadph nih3t3 ph rhythms sense sensor shift truncated
Tagcloud (Difference) ?		aminomethyl aminophenyl ato benzamide carbonyl dac deacetylases decitabine demethylation deoxycytidine dimethylated dnmt dnmt1 dnmt3b entinostat hdacs homeobox homeodomain methyltransferases potencies pyridine rhox5 rhox6 rhox9 trioxide underlining ylmethoxy	additively bmal1 box circadian clock electrophoretic ems fold heme heterodimer homodimer kd kinetics luciferase maximal metabolite mixture mobility monoxide nad nadph nih3t3 ph rhythms sense sensor shift truncated
Tagcloud (Intersection) ?