TMEM65 and SLC7A8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM65	SLC7A8
Description		transmembrane protein 65	solute carrier family 7 member 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Intercalated Disc Membrane	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane
	Molecular Function	Protein Binding	Protein Binding Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity Glycine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Antiporter Activity Thyroid Hormone Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Peptide Antigen Binding Protein Heterodimerization Activity
	Biological Process	Cardiac Ventricle Development Cardiac Conduction Regulation Of Cardiac Conduction	Amino Acid Transmembrane Transport Amino Acid Transport Neutral Amino Acid Transport L-amino Acid Transport Glycine Transport L-leucine Transport Tryptophan Transport Valine Transport Proline Transmembrane Transport Transmembrane Transport Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Transport Across Blood-brain Barrier L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane
Pathways			Basigin interactions Amino acid transport across the plasma membrane
Drugs			Phenylalanine Alanine
Diseases
GWAS		Fear of minor pain ( 28701861)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		33 interacting genes: ABHD16A AQP6 ARL13B CYB561 CYBRD1 EBP ERGIC3 FAM174A FAM209A GJA8 GPR42 HSD17B11 IGSF9 IL3RA JAGN1 JPH1 LMNA MSMO1 PDZK1IP1 PTGES PVR REEP4 RETREG3 SCN3B SLC10A6 SLC18A1 SLC35H1 SLC7A8 TIMMDC1 TMEM101 TMEM80 TMX2 ZFYVE27	26 interacting genes: ABHD16A AGPAT4 AQP6 COMT DERL1 FXYD6-FXYD2 MFF NDUFA3 NINJ2 REEP4 SIGLEC5 SLC25A46 SLC30A2 SLC33A2 SLC3A1 SLC3A2 SMPD2 SNORC SYCE1L SYNJ2BP TMEM14B TMEM208 TMEM60 TMEM65 YIPF1 YIPF6
Entrez ID		157378	23428
HPRD ID		14102	11971
Ensembl ID		ENSG00000164983	ENSG00000092068
Uniprot IDs		Q6PI78	Q53EM9 Q9UHI5
PDB IDs			7B00 7CMH 7CMI 8A6L
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Ascorbate Homeostasis Transmembrane Monodehydroascorbate Reductase Activity Endoplasmic Reticulum Transmembrane Transport Protein Binding	Membrane Golgi Trans Cisterna Golgi Medial Cisterna Sulfur Amino Acid Transport Mitochondrial Fission Mitochondrial Outer Membrane Basic Amino Acid Transport
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