PHETA2 and CLVS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHETA2	CLVS2
Description		PH domain containing endocytic trafficking adaptor 2	clavesin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle Recycling Endosome	Endosome Golgi Apparatus Trans-Golgi Network Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity	Protein Binding Lipid Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi	Lysosome Organization
Pathways			Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS			Refractive error ( 32231278) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		1 interacting genes: CLVS2	16 interacting genes: EMSY FBXW2 FLAD1 GSTM3 GSTZ1 GYS1 KAZN MEOX2 MYH7 PAFAH1B2 PCYT2 PGAM2 PHETA2 S100A7 S100A7A TACC2
Entrez ID		150368	134829
HPRD ID		17305	16666
Ensembl ID		ENSG00000177096	ENSG00000146352
Uniprot IDs		Q6ICB4	Q5SYC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Collagen Fibril Binding Negative Regulation Of Collagen Fibril Organization Phosphatidylinositol Bisphosphate Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Collagen Fibril Organization Phosphatidylinositol-3,5-bisphosphate Binding Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation Negative Regulation Of Cartilage Development Lysosome Organization Clathrin-coated Vesicle Regulation Of Cartilage Development Regulation Of Chondrocyte Differentiation Collagen Binding Regulation Of Extracellular Matrix Organization Trans-Golgi Network Membrane	Catalytic Activity Transition Metal Ion Binding Glutathione Transferase Activity Identical Protein Binding Cytosol Maleylacetoacetate Isomerase Activity Ethanolamine-phosphate Cytidylyltransferase Activity FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity
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