CDH3

Description		cadherin 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Adherens Junction Membrane Catenin Complex Cell Junction
	Molecular Function	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Retina Homeostasis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Positive Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Hair Cycle Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinization Positive Regulation Of Tyrosinase Activity Adherens Junction Organization Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Melanin Biosynthetic Process Regulation Of Transport Negative Regulation Of Timing Of Catagen Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of Melanosome Transport
Pathways		Adherens junctions interactions
Drugs
Diseases		Hypotrichosis, congenital, with juvenile macular dystrophy Ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM syndrome)
GWAS		Cutaneous melanoma or hair colour ( 32341527) Glycated hemoglobin levels ( 28898252) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 24076602 31604244) Platelet count ( 32888494) Red cell distribution width ( 27863252) Ulcerative colitis ( 28067908)
Novel Interacting Genes		1 novel interacting genes: CDH5
Interacting Genes		3 interacting genes: CTNNA1 CTNNB1 CTNND1
Entrez ID		1001
HPRD ID		00227
Ensembl ID		ENSG00000062038
Uniprot IDs		B4DLF0 P22223
PDB IDs		4OY9 4ZML 4ZMN 4ZMO 4ZMP 4ZMQ 4ZMT 4ZMV 4ZMW 4ZMX 4ZMY 4ZMZ 5JYL 5JYM 6ZTB 6ZTR 7CME 7CMF 8HYI
Enriched GO Terms of Interacting Partners?		Catenin Complex Adherens Junction Cell-cell Junction Cell-cell Adhesion Mediated By Cadherin Cadherin Binding Anchoring Junction Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Adhesion Regulation Of Blood Vessel Branching Cell-cell Junction Assembly Flotillin Complex Cell-cell Junction Organization Cell Adhesion Cell Junction Cell Migration Cell Migration Involved In Sprouting Angiogenesis Cell Junction Assembly Cell Motility Regulation Of Angiogenesis Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediator Activity Regulation Of Vasculature Development Regulation Of Endothelial Cell Differentiation Regulation Of Neuroblast Proliferation Neuroblast Proliferation Intercalated Disc Regulation Of Multicellular Organismal Development Signaling Receptor Binding Adherens Junction Organization Phosphatase Binding Regulation Of Morphogenesis Of A Branching Structure Cell Junction Organization Odontogenesis Of Dentin-containing Tooth Regulation Of Morphogenesis Of An Epithelium Endothelial Cell Migration Cell Periphery Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Odontogenesis Beta-catenin Binding Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Negative Regulation Of Blood Vessel Branching Negative Regulation Of Cell Population Proliferation Bicellular Tight Junction Transmembrane Transporter Binding Regulation Of Cell Development
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