TEPSIN and BCL2L14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TEPSIN	BCL2L14
Description		TEPSIN adaptor related protein complex 4 accessory protein	BCL2 like 14
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Membrane Coated Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane	Cytoplasm Cytosol Endomembrane System Membrane Intracellular Organelle
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding Protein Kinase Binding
	Biological Process		Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs
Diseases
GWAS		IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391)	Blood urea nitrogen levels ( 31152163) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Phosphorus levels ( 29403010) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		126 interacting genes: AATK ACBD7 AGRN AIRIM AP1M1 APOL6 APP ASAP3 ASB3 ATOSB BCL2L14 BCL2L15 BIRC7 BPIFA1 BTBD3 C1QTNF4 CBX8 CCDC146 CCNC CDC23 CINP CLCNKA CLIC3 CNTF CPNE7 CSNK2A1 CTAG1A CTAG1B CYSRT1 DEF6 DUSP29 DUSP4 DZIP1L EIF1AD FAM90A1 FARS2 FKBP6 FLACC1 FNDC3B GNG13 GOLGA2 GPANK1 GPRASP3 GRB10 GRIPAP1 GUCD1 HAT1 HCK HPCA HSF2BP HSPB7 IL16 IQGAP1 KCTD6 KCTD9 KHNYN KLHL38 KRT31 KRT34 KRT35 KRTAP6-2 LENG1 LGALS14 LMO3 LSM3 LYG2 MAT2B MED18 MFAP1 MLX MORF4L1 MSGN1 MTUS2 NDOR1 NEK6 NGB NME7 NR2C2AP NTAQ1 NUDT14 NUDT21 OAZ3 OR6B1 PAX9 PCDHB3 PLEKHA2 PSMA6 RAB3IP RAD51D RANBP3 RNF135 SEC14L4 SLU7 SNRNP25 SORBS2 SORBS3 SZT2 TAPBPL TBC1D13 TBC1D22B TCEA2 TCL1A TFAP2D THRSP TRAPPC2 TRAPPC2B TRAPPC6A TRIM23 TRIM45 TRIM50 TRIM54 TRIM68 TSEN15 TSEN2 TSHZ3 TSSK3 UBASH3B UTP23 VPS26C WDR25 YPEL3 ZIC1 ZMYND12 ZNF343 ZNF629 ZRSR2	6 interacting genes: BCL2 BCL2L1 COPS5 DDIT4L PICK1 TEPSIN
Entrez ID		146705	79370
HPRD ID		08103	05841
Ensembl ID		ENSG00000167302	ENSG00000121380
Uniprot IDs		A0A1B0GV70 Q96N21	Q9BZR8
PDB IDs		5WF9 5WFB
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Identical Protein Binding TRAPPIII Protein Complex	Dendritic Cell Apoptotic Process BH3 Domain Binding Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Negative Regulation Of Anoikis Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Regulation Of Anoikis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Epithelial Cell Apoptotic Process Ovarian Follicle Development Cellular Response To Glucose Starvation Leukocyte Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Gamma Radiation Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Leukocyte Apoptotic Process Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Apoptotic Process In Bone Marrow Cell Coated Vesicle Membrane Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Male Gonad Development Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Autophagy BAD-BCL-2 Complex Channel Inhibitor Activity Regulation Of Cellular Response To Stress Trans-Golgi Network Membrane Macrophage Migration Inhibitory Factor Binding Negative Regulation Of Signaling Mononuclear Cell Proliferation Negative Regulation Of Cell Communication Cochlear Nucleus Development Gonad Development Cellular Response To Decreased Oxygen Levels Regulation Of Nitrogen Utilization Leukocyte Proliferation
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