TEPSIN and TRIM50

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TEPSIN	TRIM50
Description		TEPSIN adaptor related protein complex 4 accessory protein	tripartite motif containing 50
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Membrane Coated Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Innate Immune Response
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391)	Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		126 interacting genes: AATK ACBD7 AGRN AIRIM AP1M1 APOL6 APP ASAP3 ASB3 ATOSB BCL2L14 BCL2L15 BIRC7 BPIFA1 BTBD3 C1QTNF4 CBX8 CCDC146 CCNC CDC23 CINP CLCNKA CLIC3 CNTF CPNE7 CSNK2A1 CTAG1A CTAG1B CYSRT1 DEF6 DUSP29 DUSP4 DZIP1L EIF1AD FAM90A1 FARS2 FKBP6 FLACC1 FNDC3B GNG13 GOLGA2 GPANK1 GPRASP3 GRB10 GRIPAP1 GUCD1 HAT1 HCK HPCA HSF2BP HSPB7 IL16 IQGAP1 KCTD6 KCTD9 KHNYN KLHL38 KRT31 KRT34 KRT35 KRTAP6-2 LENG1 LGALS14 LMO3 LSM3 LYG2 MAT2B MED18 MFAP1 MLX MORF4L1 MSGN1 MTUS2 NDOR1 NEK6 NGB NME7 NR2C2AP NTAQ1 NUDT14 NUDT21 OAZ3 OR6B1 PAX9 PCDHB3 PLEKHA2 PSMA6 RAB3IP RAD51D RANBP3 RNF135 SEC14L4 SLU7 SNRNP25 SORBS2 SORBS3 SZT2 TAPBPL TBC1D13 TBC1D22B TCEA2 TCL1A TFAP2D THRSP TRAPPC2 TRAPPC2B TRAPPC6A TRIM23 TRIM45 TRIM50 TRIM54 TRIM68 TSEN15 TSEN2 TSHZ3 TSSK3 UBASH3B UTP23 VPS26C WDR25 YPEL3 ZIC1 ZMYND12 ZNF343 ZNF629 ZRSR2	39 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620
Entrez ID		146705	135892
HPRD ID		08103	15566
Ensembl ID		ENSG00000167302	ENSG00000146755
Uniprot IDs		A0A1B0GV70 Q96N21	B7ZLG2 Q86XT4
PDB IDs		5WF9 5WFB
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Identical Protein Binding TRAPPIII Protein Complex	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein K63-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Catabolic Process TORC1 Signaling ISG15 Transferase Activity TOR Signaling Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Nucleotide Binding ISG15-protein Conjugation Protein Binding Ubiquitin Protein Ligase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Protein Destabilization Radial Spoke Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Negative Regulation Of TORC1 Signaling Protein Autoubiquitination Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Collateral Sprouting ERBB Signaling Pathway Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Negative Regulation Of Macromolecule Metabolic Process
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