ALG10B and KCNH2

Number of citations of the paper that reports this interaction (PMID 14525949)
11

Data Source:
HPRD (in vivo)

		ALG10B	KCNH2
Gene Name		ALG10B, alpha-1,2-glucosyltransferase	potassium channel, voltage gated eag related subfamily H, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nuclear Envelope Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface
	Molecular Function	Transferase Activity, Transferring Hexosyl Groups	Phosphorelay Sensor Kinase Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process	Phosphorelay Signal Transduction System Regulation Of Heart Rate By Hormone Synaptic Transmission Signal Transduction By Phosphorylation Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins	Potassium Channels Voltage gated Potassium channels
Drugs			Dofetilide Amsacrine Ibutilide Terfenadine Prazosin Sotalol Doxazosin Cisapride Astemizole Verapamil Thioridazine Quinidine Pimozide Miconazole Amiodarone Carvedilol Terazosin Propafenone Halofantrine Dronedarone Sertindole
Diseases
GWAS		Drug-induced liver injury (flucloxacillin) ( 19483685)	Electrocardiographic traits ( 20062061 20062063) QT interval ( 23166209 19305408 19305409)
Protein-Protein Interactions		1 interactors: KCNH2	10 interactors: ALG10 ALG10B CDC73 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH
Entrez ID		144245	3757
HPRD ID		11923	01069
Ensembl ID			ENSG00000055118
Uniprot IDs		Q5I7T1	Q12809 Q15BH2
PDB IDs			1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 4HP9 4HQA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Regulation Of Heart Rate By Hormone Peptidyl-histidine Phosphorylation Regulation Of Heart Rate By Chemical Signal Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Membrane Depolarization During Action Potential Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Negative Regulation Of Ion Transmembrane Transport Cardiac Muscle Contraction Negative Regulation Of Transmembrane Transport Cellular Response To Drug Regulation Of Potassium Ion Transport Heart Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Striated Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Negative Regulation Of Ion Transport Membrane Depolarization Regulation Of Muscle Contraction Regulation Of Heart Contraction Potassium Ion Transmembrane Transport Positive Regulation Of Ion Transport Potassium Ion Transport Muscle Contraction Muscle System Process Regulation Of Membrane Potential Signal Transduction By Phosphorylation Blood Circulation Negative Regulation Of Transport Regulation Of Actin Filament-based Process	Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cardiac Conduction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Regulation Of Heart Rate Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Striated Muscle Contraction Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein N-linked Glycosylation Ventricular Cardiac Muscle Cell Action Potential Regulation Of Muscle Contraction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Positive Regulation Of Intracellular Transport Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Dolichol-linked Oligosaccharide Biosynthetic Process Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Glycosylation Macromolecule Glycosylation Glycosylation Apoptotic Signaling Pathway Glucocorticoid Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Glycoprotein Biosynthetic Process Midbrain Development Carbohydrate Metabolic Process Regulation Of Intracellular Transport
Tagcloud ?			1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Difference) ?			1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Intersection) ?