PRICKLE1 and TYR

		PRICKLE1	TYR
Description		prickle planar cell polarity protein 1	tyrosinase
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Postsynaptic Density Membrane Cell Trailing Edge Nuclear Membrane Glutamatergic Synapse	Cytoplasm Lysosome Golgi-associated Vesicle Membrane Melanosome Membrane Melanosome Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Protein-containing Complex Binding Metal Ion Binding	Monooxygenase Activity Tyrosinase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Neural Tube Closure Tissue Homeostasis Outflow Tract Morphogenesis Protein Import Into Nucleus Apoptotic Process Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Axonogenesis Heart Development Response To Xenobiotic Stimulus Animal Organ Morphogenesis Tissue Development Gene Expression Programmed Cell Death Wnt Signaling Pathway Vesicle-mediated Transport Dendrite Development Cell Migration Establishment Of Cell Polarity Bone Mineralization Embryonic Limb Morphogenesis Cytoskeleton-dependent Intracellular Transport Neuron Projection Development Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Limb Morphogenesis Multicellular Organism Growth Embryonic Nail Plate Morphogenesis Aorta Development Post-anal Tail Morphogenesis Embryonic Digit Morphogenesis Cilium Organization Establishment Of Protein Localization Negative Regulation Of DNA-templated Transcription Neuron Projection Morphogenesis Response To Electrical Stimulus Cardiac Muscle Cell Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Cilium Assembly Face Morphogenesis Mesenchyme Development Coronary Vasculature Development Eyelid Development In Camera-type Eye Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Cornea Development In Camera-type Eye Renal Tubule Development Polarized Secretion Of Basement Membrane Proteins In Epithelium Tear Secretion Basement Membrane Organization Extracellular Matrix Assembly Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Cell-cell Adhesion Regulation Of Postsynaptic Density Assembly Maintenance Of Postsynaptic Density Structure Focal Adhesion Disassembly Anterior Visceral Endoderm Cell Migration Neuron Projection Extension Embryonic Brain Development Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Population Proliferation Response To UV Response To Blue Light Response To Vitamin D Melanin Biosynthetic Process Pigmentation Thymus Development Response To CAMP
Pathways		Asymmetric localization of PCP proteins	Melanin biosynthesis Regulation of MITF-M-dependent genes involved in pigmentation
Drugs			NADH Azelaic acid Monobenzone Mimosine Hydroquinone Arbutin Hexylresorcinol
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)	Oculocutaneous albinism (OCA)
GWAS		Appendicular lean mass ( 33097823) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Age-related hearing impairment ( 34108613) Age-related macular degeneration ( 23326517) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Basal cell carcinoma ( 33549134 27539887 31174203) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 17952075) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eye color ( 20585627) Eye color (brightness) ( 30664655) Fish- and plant-related diet ( 32066663) Freckles ( 17952075) Hair color ( 26926045 30664655 29662168) Intraocular pressure ( 29617998) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Macular thickness ( 30535121) Melanoma ( 19578364 21983787 24980573 28212542) Neurociticism ( 29500382) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-melanoma skin cancer ( 29739929) Optic disc size ( 31809533) Skin pigmentation ( 31315583 30664655 17999355) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518 20410501 27723757)
Interacting Genes		7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP	1 interacting genes: TYRP1
Entrez ID		144165	7299
HPRD ID		16341	06086
Ensembl ID		ENSG00000139174	ENSG00000077498
Uniprot IDs		B3KVG3 B3KVG6 Q96MT3	L8B082 P14679
PDB IDs			7RK7
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Endocytosis Regulation Of Endocytosis Golgi-associated Vesicle Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dendrite Cytoplasm Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Clathrin Binding Lysosome Organization Positive Regulation Of Signal Transduction Regulation Of Vacuole Organization Regulation Of Vesicle-mediated Transport Tyrosinase Activity Eye Pigment Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Epinephrine Secretion Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Positive Regulation Of Clathrin Coat Assembly U4atac SnRNP Ribonucleoprotein Complex Localization ISWI-type Complex Regulation Of Locomotion Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Activation Of Blood Coagulation Via Clotting Cascade Phosphatidylserine Exposure On Blood Platelet Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Cell Population Proliferation Melanin Biosynthetic Process From Tyrosine Prolactin Secretion Regulation Of Wnt Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Acetoacetic Acid Metabolic Process Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Tyrosinase Activity Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Extracellular Matrix Constituent Secretion Tear Secretion Embryonic Nail Plate Morphogenesis Maintenance Of Postsynaptic Density Structure Ketone Body Metabolic Process Positive Regulation Of Melanin Biosynthetic Process Maintenance Of Postsynaptic Specialization Structure Cornea Development In Camera-type Eye Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Melanin Biosynthetic Process Primitive Streak Formation Eyelid Development In Camera-type Eye Negative Regulation Of Cardiocyte Differentiation Melanocyte Differentiation Short-chain Fatty Acid Metabolic Process Bounding Membrane Of Organelle Intracellular Vesicle Post-anal Tail Morphogenesis Embryonic Brain Development Regulation Of Postsynaptic Specialization Assembly Regulation Of Postsynaptic Density Assembly Regulation Of Excitatory Synapse Assembly Postsynaptic Density Organization Pigment Cell Differentiation Melanosome Membrane Postsynaptic Specialization Organization Negative Regulation Of Stem Cell Differentiation Renal Tubule Development Coronary Vasculature Development Negative Regulation Of T Cell Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Maintenance Of Synapse Structure Aorta Development Extracellular Matrix Assembly Basement Membrane Organization Negative Regulation Of Myoblast Differentiation Face Morphogenesis Melanosome Organization Pigment Granule Organization Response To Electrical Stimulus Cardiac Muscle Cell Development
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