CERK and NHLRC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CERK	NHLRC4
Description		ceramide kinase	NHL repeat containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Ceramide Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Biosynthetic Process
Pathways		Glycosphingolipid biosynthesis
Drugs
Diseases
GWAS		Aseptic loosening in total joint arthroplasty ( 31791832) Triglyceride levels ( 30108155)	Mean corpuscular hemoglobin concentration ( 27863252)
Interacting Genes		21 interacting genes: ALAS1 APP CRYBA1 CYSRT1 KRT34 KRTAP1-1 KRTAP10-3 KRTAP11-1 KRTAP19-1 KRTAP19-6 KRTAP3-1 KRTAP3-2 KRTAP6-2 KRTAP9-2 MTUS2 NBPF19 NHLRC4 NOTCH2NLA OIP5 PLEKHF2 TRIM42	20 interacting genes: CERK DDIT4L DMRT3 DTX2 ENKD1 HSF4 IGFN1 KRTAP13-2 KRTAP15-1 KRTAP26-1 MGAT5B MYLIP OTX1 PATZ1 PITX1 POGZ POU4F3 PRKAB2 SPAG8 TLX3
Entrez ID		64781	283948
HPRD ID		09878	11681
Ensembl ID		ENSG00000100422	ENSG00000257108
Uniprot IDs		Q8TCT0	P0CG21
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Molecule Activity	Sequence-specific Double-stranded DNA Binding Chromatin DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Diencephalon Morphogenesis Neuron Fate Specification Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Intermediate Filament
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