CREM and AMBRA1

		CREM	AMBRA1
Description		cAMP responsive element modulator	autophagy and beclin 1 regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Membrane ATF4-CREB1 Transcription Factor Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Cytosol Cytoskeleton Focal Adhesion Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding GTPase Binding Protein Phosphatase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Glycosphingolipid Metabolic Process Signal Transduction Spermatogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process CAMP/PKA Signal Transduction	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitophagy Regulation Of Transcription By RNA Polymerase II Autophagy Nervous System Development Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Ubiquitination Neural Tube Development Cell Differentiation Response To Nutrient Levels Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Mitochondrial Depolarisation Positive Regulation Of Mitophagy Positive Regulation Of Free Ubiquitin Chain Polymerization Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 23128233 28067908)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)
Interacting Genes		45 interacting genes: ATF1 ATXN1 BHLHE40 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 DNMT3L EMP3 FHL5 GLIS2 GSK3A GSK3B HDAC1 HPCA HPCAL1 KCNIP3 MAPK3 MKNK1 MYOZ3 NCALD NCS1 PIAS3 POU2F1 PRKACA PRKCA RHOXF2 ROR2 RUSC1 SNRPB SNRPC SP100 SPI1 TAF4 TBP UBAP2 UBE2I VENTX	15 interacting genes: AKT1 BECN1 CCND1 CHUK GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MTOR RNF2 SNCA UBC UBE2D3
Entrez ID		1390	55626
HPRD ID		00444	10975
Ensembl ID		ENSG00000095794	ENSG00000110497
Uniprot IDs		E9PAR2 E9PB41 Q03060	A0A075B6T1 Q9C0C7
PDB IDs			8WQR
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Protein Serine Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Kinase Activity Protein Serine/threonine Kinase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Gene Expression Kinase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Protein Modification Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Protein Localization Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Transferase Activity CAMP/PKA Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction ATP Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Assembly Autophagosome Maturation Autophagosome Organization Mitophagy Cellular Response To Starvation Response To Starvation Autophagy Of Mitochondrion Autophagosome Cellular Response To Nutrient Levels Macroautophagy Vacuole Organization Autophagosome Membrane Phospholipid Binding Response To Nutrient Levels Protein-containing Complex Disassembly Autophagy Ubiquitin Protein Ligase Binding Response To Iron(II) Ion Response To Iron Ion Cellular Response To Stress Beta-tubulin Binding Cellular Response To Amino Acid Starvation GABA Receptor Binding Response To Amino Acid Starvation Organelle Assembly Cellular Response To Copper Ion Cytoplasmic Vesicle Negative Regulation Of Catabolic Process Catabolic Process Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Negative Regulation Of Autophagy Response To Copper Ion Negative Regulation Of Macroautophagy Microtubule Binding Organelle Organization Endomembrane System Regulation Of Generation Of Precursor Metabolites And Energy Response To Stress Organelle Membrane Cellular Response To Decreased Oxygen Levels Response To Vitamin E Generation Of Precursor Metabolites And Energy Cellular Response To Oxygen Levels Response To Metal Ion Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Mitochondrial ATP Synthesis Coupled Electron Transport Microtubule
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