PTPDC1 and LMTK2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		PTPDC1	LMTK2
Description		protein tyrosine phosphatase domain containing 1	lemur tyrosine kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cytoplasm Early Endosome Golgi Apparatus Endomembrane System Membrane Growth Cone Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin VI Binding Protein Serine Kinase Activity
	Biological Process	Cell Projection Organization Cilium Assembly	Receptor Recycling Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endocytic Recycling Transferrin Transport Early Endosome To Late Endosome Transport Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS		Birth weight ( 31043758) Esophageal adenocarcinoma ( 24121790) Heel bone mineral density ( 30598549) Height ( 20881960) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Parkinson's disease ( 26227905) Type 2 diabetes ( 30054458) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Gamma glutamyl transferase levels ( 29403010 33339817) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		7 interacting genes: AATK CRKL ERBB3 ERBB4 LMTK2 MID2 TEX11	24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2
Entrez ID		138639	22853
HPRD ID		06689	13994
Ensembl ID		ENSG00000158079	ENSG00000164715
Uniprot IDs		A0A087WTF0 A2A3K4 A8K0X7	Q8IWU2
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity Cell Death Apoptotic Process Programmed Cell Death Protein Tyrosine Kinase Activity Protein Kinase Activity ERBB2 Signaling Pathway Kinase Activity Animal Organ Development Heart Development Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Neuromuscular Junction ERBB Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis Meiotic Gene Conversion Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Helper T Cell Diapedesis Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Central Nervous System Morphogenesis Myosin VI Binding Gene Conversion Male Gonad Development Neuron Apoptotic Process Chordate Pharynx Development Cerebellar Neuron Development ATP Binding Protein Autophosphorylation Epidermal Growth Factor Receptor Activity Male Meiosis Chromosome Segregation Gonad Development Fertilization Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Parathyroid Gland Development ERBB4-ERBB4 Signaling Pathway Chiasma Assembly Reproductive Structure Development	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Dephosphorylation Hydrolase Activity Cation Binding Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Phosphatase Activity PTW/PP1 Phosphatase Complex Protein Modification Process Glycogen Metabolic Process Cytoplasm Negative Regulation Of MAPK Cascade Peptidyl-tyrosine Dephosphorylation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Kinase 5 Complex Photoperiodism Entrainment Of Circadian Clock Cytosol MAPK Cascade Rhythmic Process Cell Division Protein Kinase Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Nucleoplasm Protein Metabolic Process Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Phosphatase Activity Layer Formation In Cerebral Cortex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Protein Phosphatase 1 Binding Positive Regulation Of Protein Targeting To Membrane Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Signaling Regulation Of Establishment Of Protein Localization
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