SRSF12 and EIF5B

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SRSF12	EIF5B
Description		serine and arginine rich splicing factor 12	eukaryotic translation initiation factor 5B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RS Domain Binding Unfolded Protein Binding	TRNA Binding Nucleotide Binding RNA Binding Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Processing RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome	Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Serum metabolite levels ( 33031748)	Bipolar disorder ( 21926972)
Interacting Genes		5 interacting genes: CDK6 CLK1 EIF5B SRPK1 SRPK2	14 interacting genes: BRCA1 CBL CDC42 CEBPA CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 SIRPA SRSF12 TFCP2 WBP4 ZBTB3
Entrez ID		135295	9669
HPRD ID		11605	07304
Ensembl ID		ENSG00000154548	ENSG00000158417
Uniprot IDs		Q8WXF0	O60841 Q8N5A0
PDB IDs			7TQL 8PJ3 8PJ4 8PJ5
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Nucleotide Binding Kinase Activity Regulation Of RNA Splicing Positive Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process ATP Binding Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Cyclin D2-CDK6 Complex Regulation Of Viral Life Cycle Regulation Of MRNA Splicing, Via Spliceosome Transferase Activity Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Regulation Of MRNA Processing Regulation Of Viral Process Nuclear Speck Organization Gliogenesis Negative Regulation Of Monocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Cell Dedifferentiation Regulation Of Gene Expression Magnesium Ion Binding Protein-RNA Complex Assembly Regulation Of Primary Metabolic Process Response To Other Organism R-loop Processing Regulation Of Macromolecule Metabolic Process Type B Pancreatic Cell Development Regulation Of MRNA Metabolic Process Lateral Ventricle Development Response To External Biotic Stimulus Protein Phosphorylation RNA Splicing Regulation Of Hematopoietic Stem Cell Differentiation Phosphorylation Astrocyte Development Regulation Of Monocyte Differentiation Regulation Of Metabolic Process Nuclear Body Organization Hematopoietic Stem Cell Differentiation Generation Of Neurons Nuclear Speck Sperm DNA Condensation	Response To Ionizing Radiation Regulation Of Cell Cycle Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Endocytosis Response To Radiation Protein Tyrosine Kinase Binding RNA Metabolic Process Positive Regulation Of Cytokinesis Macrophage Differentiation Response To Peptide Response To Cytokine DNA Recombination RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleoplasm Histone H2AK129 Ubiquitin Ligase Activity Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Protein Autoubiquitination BRCA1-BARD1 Complex GBD Domain Binding Storage Vacuole Cellular Response To Type II Interferon Positive Regulation Of DNA-templated Transcription Initiation Response To Vitamin B2 C/EBP Complex MRNA Metabolic Process Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-12 BRCA1-B Complex Positive Regulation Of Metabolic Process DNA Damage Response Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Protein-containing Complex Regulation Of Macromolecule Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II
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