PDCL2 and UNC13B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDCL2	UNC13B
Description		phosducin like 2	unc-13 homolog B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Terminal Bouton Synapse Presynaptic Active Zone
	Molecular Function		Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Acrosome Assembly Protein Folding Spermatogenesis Spermatid Development Sperm Axoneme Assembly Cell Differentiation Flagellated Sperm Motility Sperm Flagellum Assembly	Exocytosis Chemical Synaptic Transmission Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Secretion Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Parkinson's disease ( 21812969)
Interacting Genes		5 interacting genes: GOLGA1 HYCC2 STEEP1 UNC13B YWHAB	12 interacting genes: CFAP298 CLK1 DOC2A DOC2B PDCL2 RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		132954	10497
HPRD ID		15109	05785
Ensembl ID		ENSG00000163440	ENSG00000198722
Uniprot IDs		Q8N4E4	A0A1B0GUS7 A0A1B0GVW8 O14795
PDB IDs		3EVI
Enriched GO Terms of Interacting Partners?			Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Secretion By Cell Vesicle-mediated Transport In Synapse Calcium-ion Regulated Exocytosis Neurotransmitter Transport Regulated Exocytosis Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Regulated Secretory Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Synaptic Vesicle Docking Signal Release Vesicle Docking Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Exocytosis Vesicle-mediated Transport Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Membrane Docking Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Vesicle-mediated Transport Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Positive Regulation Of Secretion By Cell Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Secretion Regulation Of Secretion Regulation Of Vesicle Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Membrane Fusion Modulation Of Excitatory Postsynaptic Potential SNARE Binding Presynapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Establishment Of Localization In Cell Regulation Of Synaptic Vesicle Priming Regulation Of Neurotransmitter Secretion Vesicle Fusion Organelle Membrane Fusion Synaptic Vesicle Membrane Organization
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