TMEM182 and TSPAN12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM182	TSPAN12
Description		transmembrane protein 182	tetraspanin 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Wnt Receptor Activity
	Biological Process	Muscle Organ Development Myotube Cell Development Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Negative Regulation Of Myoblast Differentiation Negative Regulation Of Myoblast Fusion	Angiogenesis Cell Surface Receptor Signaling Pathway Retina Layer Formation Maintenance Of Blood-brain Barrier Regulation Of Angiogenesis Norrin Signaling Pathway
Pathways
Drugs
Diseases			Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Blood pressure ( 24903457) Blood pressure (anthropometric measures interaction) ( 24903457) Chromium levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophilic esophagitis ( 34506852) General risk tolerance (MTAG) ( 30643258) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) PR interval ( 30046033 32439900) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (current vs never) ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Sun-seeking behavior ( 32920024)	Bitter alcoholic beverage consumption ( 31046077) Heel bone mineral density ( 30598549)
Interacting Genes		15 interacting genes: CLDN5 FNDC9 GJA8 GPR42 KLRC1 MALL MS4A3 PLP1 SMIM3 SUSD3 SYNE4 TMEM140 TMEM218 TMEM31 TSPAN12	21 interacting genes: CDS2 CTXN3 CXCL16 CYBC1 EMP3 GPR25 GPR37L1 IGFBP5 MARCHF2 MGST3 NINJ2 PMP22 RFT1 RNF152 STX8 TEX264 TFCP2 TMEM140 TMEM147 TMEM182 TMEM218
Entrez ID		130827	23554
HPRD ID		08698	15509
Ensembl ID		ENSG00000170417	ENSG00000106025
Uniprot IDs		A0A494C0U9 B8ZZ71 Q6ZP80	O95859
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Myelination Axon Ensheathment Structural Constituent Of Myelin Sheath Maintenance Of Blood-brain Barrier Inhibitory MHC Class Ib Receptor Activity	Membrane Bleb Assembly Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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